Annual report pursuant to Section 13 and 15(d)

Supplemental Disclosure for Statements of Cash Flows (Details)

v3.3.1.900
Supplemental Disclosure for Statements of Cash Flows (Details) - USD ($)
 1 Months Ended 12 Months Ended
Jul. 31, 2015
Mar. 31, 2015
Jul. 31, 2014
Jun. 30, 2013
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Jul. 15, 2014
Cash paid during the period for interest         $ 4,600,000 $ 2,900,000 $ 1,900,000  
Issued stock for payment of milestone fee, shares             100,000  
Issued stock for payment of milestone fee, value             $ 166,000  
Issued stock to 401(k) plan, shares         68,157 36,455 22,126  
Issued stock to 401(k) plan for employer matching contributions         $ 117,099 $ 100,043 $ 66,777  
Notes payable end of term fees         1,000,000 2,400,000 1,000,000  
Repayments of notes payable $ 333,333   $ 666,666   30,333,333 25,000,000 5,982,155  
Derivative liabilities         63,000 0    
Deemed dividend on beneficial conversion feature of MT Preferred Stock         $ 46,000      
R-NAV [Member]                
Repayments of notes payable $ 333,333              
Promissory note payable           666,666   $ 666,666
Platinum Montaur Life Sciences Llc [Member]                
Repayments of notes payable       $ 4,781,333     4,800,000  
General Electric Capital Corporation/MidCap Financial SBIC, LP [Member]                
Estimated fair value of warrants issued             631,000  
Crede CG III, Ltd. [Member]                
Estimated fair value of warrants issued             $ 7,700,000  
Oxford Finance, LLC [Member]                
Estimated fair value of warrants issued           $ 465,000    
Series B Preferred Stock [Member]                
Conversion of Series B preferred stock to common stock, shares       2,364.9     2,364.9  
Convertible Preferred Stock [Member]                
Deemed dividend on beneficial conversion feature of MT Preferred Stock   $ 46,000            
Convertible Preferred Stock [Member] | Macrophage Therapeutics [Member]                
Deemed dividend on beneficial conversion feature of MT Preferred Stock   $ 46,000