FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BUPP DAVID C
   2. Issuer Name and Ticker or Trading Symbol
NEOPROBE CORP [NEOP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
CEO and President
(Last)
(First)
(Middle)
425 METRO PLACE NORTH, SUITE 300		 3. Date of Earliest Transaction (Month/Day/Year)
06/24/2010
(Street)

DUBLIN, OH 43017		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/01/2010   W V 40,000 D $ 0 940,649 D  
Common Stock 04/13/2011   M   300,000 A $ 0.27 1,255,649 D  
Common Stock 04/13/2011   M   200,000 A $ 0.39 1,455,649 D  
Common Stock 04/13/2011   M   200,000 A $ 0.36 1,655,649 D  
Common Stock 04/13/2011   M   200,000 A $ 0.26 1,855,649 D  
Common Stock 04/13/2011   M   180,000 A $ 0.42 2,035,649 D  
Common Stock 04/13/2011   M   150,000 A $ 0.49 2,185,649 D  
Common Stock 04/13/2011   M   125,000 A $ 0.3 2,310,649 D  
Common Stock 04/13/2011   M   100,000 A $ 0.14 2,410,649 D  
Common Stock 04/13/2011   M   70,000 A $ 0.13 2,480,649 D  
Common Stock 04/13/2011   F   637,321 D $ 0.32 (1) 1,843,328 D  
Common Stock               125,972 I By 401(k)
Common Stock               193,746 I By Spouse

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
10% Convertible Note Due 07/08/08 $ 0.31 06/24/2010   C     3,225,806 07/03/2007 07/08/2008 Common Stock 3,225,806 $ 0.31 0 D  
8% Convertible Preferred Stock $ 0.31 06/24/2010   C   1,613,000     (2)   (2) Common Stock 1,613,000 $ 0 1,613,000 D  
Stock Option (Right to Buy) $ 0.36 04/13/2011   M     200,000   (3) 01/03/2018 Common Stock 200,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.42 04/13/2011   M     180,000   (4) 01/07/2012 Common Stock 180,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.3 04/13/2011   M     125,000   (4) 01/07/2014 Common Stock 125,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.14 04/13/2011   M     100,000   (4) 01/15/2013 Common Stock 100,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.13 04/13/2011   M     70,000   (4) 02/17/2013 Common Stock 70,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.49 04/13/2011   M     150,000   (4) 07/28/2014 Common Stock 150,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.39 04/13/2011   M     200,000   (4) 12/10/2014 Common Stock 200,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.27 04/13/2011   M     300,000   (4) 12/15/2016 Common Stock 300,000 $ 0 0 D  
Stock Option (Right to Buy) $ 0.26 04/13/2011   M     200,000   (5) 12/27/2015 Common Stock 200,000 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BUPP DAVID C
425 METRO PLACE NORTH
SUITE 300
DUBLIN, OH 43017		   X     CEO and President  

Signatures

 William J. Kelly, Jr., Attorney-In-Fact   04/15/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Price represents a weighted average ranging from $0.13 to $0.49. Upon the request by the SEC staff, the Issuer, or a security holder of the Issuer, the reporting person will provide the full information about the number of shares withheld at each separate price.
(2) The 8% Convertible Preferred Stock is convertible into common stock at any time and has no expiration date.
(3) Option vests on specific milestones.
(4) Option vests 1/3 of the underlying shares annually beginning on the first anniversary of the date of grant.
(5) Option vests 1/3 of the underlying shares beginning on the date of grant and vests thereafter 1/3 of the underlying shares on each of the first and second

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