Note 14 - Segments - Segment Information (Details) - USD ($)
|
3 Months Ended |
9 Months Ended |
|
Sep. 30, 2020 |
Jun. 30, 2020 |
Mar. 31, 2020 |
Sep. 30, 2019 |
Jun. 30, 2019 |
Mar. 31, 2019 |
Sep. 30, 2020 |
Sep. 30, 2019 |
Dec. 31, 2019 |
Revenue from contract with customer |
|
$ 7,000
|
|
|
$ 5,000
|
|
|
$ 31,000
|
$ 35,000
|
|
Grant and other revenue |
|
261,616
|
|
|
231,916
|
|
|
664,848
|
514,589
|
|
Revenues, Total |
|
268,389
|
|
|
236,811
|
|
|
695,762
|
538,527
|
|
Cost of revenue |
|
82
|
|
|
195
|
|
|
1,048
|
6,559
|
|
Research and development expenses |
|
1,377,998
|
|
|
1,801,558
|
|
|
3,659,046
|
3,612,783
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,773,532
|
|
|
1,485,207
|
|
|
4,894,778
|
5,001,818
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
15,402
|
|
|
34,289
|
|
|
51,501
|
107,794
|
|
(Loss) income from operations (3) |
[3] |
(2,898,625)
|
|
|
(3,084,438)
|
|
|
(7,910,611)
|
(8,190,427)
|
|
Other expense (4) |
[4] |
(713)
|
|
|
10,334
|
|
|
12,045
|
17,456
|
|
Net (loss) income |
|
(2,899,338)
|
$ (2,325,619)
|
$ (2,673,608)
|
(3,074,104)
|
$ (2,673,179)
|
$ (2,429,061)
|
(7,898,566)
|
(8,176,343)
|
|
Total assets, net of depreciation and amortization |
|
5,995,835
|
|
|
|
|
|
5,995,835
|
|
$ 4,150,906
|
International |
|
5,995,835
|
|
|
|
|
|
5,995,835
|
|
$ 4,150,906
|
Capital expenditures |
|
120,810
|
|
|
|
|
|
129,216
|
|
|
Income tax (expense) benefit |
|
|
|
|
|
|
|
|
(707)
|
|
(Loss) income from operations (3) |
[3] |
(2,898,625)
|
|
|
(3,084,438)
|
|
|
(7,910,611)
|
(8,190,427)
|
|
Other income (4) |
[4] |
(713)
|
|
|
10,334
|
|
|
12,045
|
17,456
|
|
Net (loss) income |
|
(2,899,338)
|
$ (2,325,619)
|
$ (2,673,608)
|
(3,074,104)
|
$ (2,673,179)
|
$ (2,429,061)
|
(7,898,566)
|
(8,176,343)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
(8,173,678)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
(2,665)
|
|
UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
5,879,053
|
|
|
4,819,050
|
|
|
5,879,053
|
4,819,050
|
|
International |
|
5,879,053
|
|
|
4,819,050
|
|
|
5,879,053
|
4,819,050
|
|
Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
116,782
|
|
|
2,606
|
|
|
116,782
|
2,606
|
|
International |
|
116,782
|
|
|
2,606
|
|
|
116,782
|
2,606
|
|
Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
2,047
|
|
|
4,895
|
|
|
26,188
|
13,985
|
|
License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
4,726
|
|
|
|
|
|
4,726
|
9,953
|
|
Diagnostics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
106,729
|
|
|
77,049
|
|
|
381,103
|
309,670
|
|
Revenues, Total |
|
113,502
|
|
|
81,944
|
|
|
412,017
|
333,608
|
|
Cost of revenue |
|
82
|
|
|
195
|
|
|
1,048
|
6,559
|
|
Research and development expenses |
|
1,251,383
|
|
|
1,678,423
|
|
|
3,402,160
|
3,194,468
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
4,027
|
|
|
|
|
|
4,027
|
|
|
(Loss) income from operations (3) |
[3] |
(1,268,605)
|
|
|
(1,596,674)
|
|
|
(2,995,218)
|
(2,867,419)
|
|
Other expense (4) |
[4] |
|
|
|
|
|
|
|
|
|
Net (loss) income |
|
(1,141,990)
|
|
|
(1,596,746)
|
|
|
(2,995,218)
|
(2,870,332)
|
|
Capital expenditures |
|
120,810
|
|
|
|
|
|
120,810
|
|
|
Income tax (expense) benefit |
|
|
|
|
(72)
|
|
|
|
(248)
|
|
(Loss) income from operations (3) |
[3] |
(1,268,605)
|
|
|
(1,596,674)
|
|
|
(2,995,218)
|
(2,867,419)
|
|
Other income (4) |
[4] |
|
|
|
|
|
|
|
|
|
Net (loss) income |
|
(1,141,990)
|
|
|
(1,596,746)
|
|
|
(2,995,218)
|
(2,870,332)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
(2,867,667)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
(2,665)
|
|
Diagnostics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
1,000
|
|
|
36,811
|
|
|
1,000
|
36,811
|
|
International |
|
1,000
|
|
|
36,811
|
|
|
1,000
|
36,811
|
|
Diagnostics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
116,782
|
|
|
2,606
|
|
|
116,782
|
2,606
|
|
International |
|
116,782
|
|
|
2,606
|
|
|
116,782
|
2,606
|
|
Diagnostics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
2,047
|
|
|
4,895
|
|
|
26,188
|
13,985
|
|
Diagnostics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
4,726
|
|
|
|
|
|
4,726
|
9,953
|
|
Therapeutics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
154,887
|
|
|
154,867
|
|
|
283,745
|
204,919
|
|
Revenues, Total |
|
154,887
|
|
|
154,867
|
|
|
283,745
|
204,919
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
126,615
|
|
|
123,135
|
|
|
256,886
|
418,315
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
1,052
|
|
|
(550)
|
15,828
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
|
|
|
|
|
|
|
|
|
(Loss) income from operations (3) |
[3] |
28,272
|
|
|
30,680
|
|
|
27,409
|
(229,224)
|
|
Other expense (4) |
[4] |
|
|
|
|
|
|
|
|
|
Net (loss) income |
|
28,272
|
|
|
30,696
|
|
|
27,409
|
(229,244)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
Income tax (expense) benefit |
|
|
|
|
16
|
|
|
|
(20)
|
|
(Loss) income from operations (3) |
[3] |
28,272
|
|
|
30,680
|
|
|
27,409
|
(229,224)
|
|
Other income (4) |
[4] |
|
|
|
|
|
|
|
|
|
Net (loss) income |
|
28,272
|
|
|
30,696
|
|
|
27,409
|
(229,244)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
(229,244)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
38,320
|
|
|
93,860
|
|
|
38,320
|
93,860
|
|
International |
|
38,320
|
|
|
93,860
|
|
|
38,320
|
93,860
|
|
Therapeutics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
International |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
|
Revenues, Total |
|
|
|
|
|
|
|
|
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
|
|
|
|
|
|
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,773,532
|
|
|
1,484,155
|
|
|
4,895,328
|
4,985,990
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
11,375
|
|
|
34,289
|
|
|
47,474
|
107,794
|
|
(Loss) income from operations (3) |
[3] |
(1,784,907)
|
|
|
(1,518,444)
|
|
|
(4,942,802)
|
(5,093,784)
|
|
Other expense (4) |
[4] |
(713)
|
|
|
10,334
|
|
|
12,045
|
17,456
|
|
Net (loss) income |
|
(1,785,620)
|
|
|
(1,508,055)
|
|
|
(4,930,757)
|
(5,076,767)
|
|
Capital expenditures |
|
|
|
|
|
|
|
8,406
|
|
|
Income tax (expense) benefit |
|
|
|
|
55
|
|
|
|
(439)
|
|
(Loss) income from operations (3) |
[3] |
(1,784,907)
|
|
|
(1,518,444)
|
|
|
(4,942,802)
|
(5,093,784)
|
|
Other income (4) |
[4] |
(713)
|
|
|
10,334
|
|
|
12,045
|
17,456
|
|
Net (loss) income |
|
(1,785,620)
|
|
|
(1,508,055)
|
|
|
(4,930,757)
|
(5,076,767)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
(5,076,767)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
5,839,733
|
|
|
4,688,379
|
|
|
5,839,733
|
4,688,379
|
|
International |
|
5,839,733
|
|
|
4,688,379
|
|
|
5,839,733
|
4,688,379
|
|
Corporate Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
International |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
|
|