Annual report pursuant to Section 13 and 15(d)

Note 2 - Liquidity (Details Textual)

v3.8.0.1
Note 2 - Liquidity (Details Textual) - USD ($)
1 Months Ended
Jan. 16, 2018
Nov. 02, 2017
Mar. 31, 2017
Mar. 03, 2017
Mar. 01, 2017
Jun. 22, 2016
Dec. 31, 2017
Feb. 28, 2017
Dec. 31, 2016
May 31, 2015
Estimated Litigation Liability, Current             $ 2,887,566    
CRG Loan Agreement, Ohio Case [Member]                    
Release of Cash Held in Escrow       $ 2,000,000            
CRG Loan Agreement, Texas Case [Member]                    
Release of Cash Held in Escrow       3,000,000            
Estimated Litigation Liability, Current             2,900,000      
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                    
Loss Contingency, Damages Awarded, Value, Additional Amount       7,000,000     7,000,000      
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration             4,100,000      
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member] | Subsequent Event [Member]                    
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration $ 4,100,000                  
CRG Loan Agreement, Texas Case [Member] | Pending Litigation [Member] | Subsequent Event [Member]                    
Loss Contingency, Damages Awarded,Value, Requested Modified Amount $ 2,900,000                  
Platinum-Montaur Life Sciences LLC Litigation [Member] | Pending Litigation [Member]                    
Loss Contingency, Damages Sought, Value   $ 1,914,827.22                
Maximum [Member] | CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                    
Loss Contingency, Damages Awarded, Value       66,000,000     $ 66,000,000      
Term Loan Agreement [Member] | Cardinal Health 414 [Member]                    
Letters of Credit Outstanding, Amount       7,000,000            
Term Loan Agreement [Member] | CRG [Member]                    
Letters of Credit Outstanding, Amount       12,000,000            
CRG [Member] | Term Loan Agreement [Member]                    
Debt Instrument, Interest Rate, Stated Percentage               14.00%   14.00%
Debt Instrument, Default, Interest Rate, Stated Percentage               18.00%    
Primary Bank Account Cash Taken Possession Of By Creditor           $ 4,100,000        
Repayments of Debt       59,000,000            
Debt Instrument, Final Payoff Amount, Threshold Above Which the Reporting Entity Will First Pay Without Resorting to Letter of Credit       59,000,000            
CRG [Member] | Term Loan Agreement [Member] | CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                    
Repayments of Debt     $ 59,000,000 59,000,000 $ 59,000,000          
CRG [Member] | Term Loan Agreement [Member] | Minimum [Member]                    
Debt Instrument, Agreed-upon Final Payoff Amount       47,000,000            
CRG [Member] | Term Loan Agreement [Member] | Maximum [Member]                    
Debt Instrument, Agreed-upon Final Payoff Amount       66,000,000            
PPCO [Member] | Platinum Loan Agreement [Member]                    
Repayments of Debt       7,700,000            
Convertible Debt       $ 1,900,000