Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' Equity (Deficit)

v2.4.0.8
Consolidated Statements of Stockholders' Equity (Deficit) (USD $)
Total
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Deficit [Member]
Balance at Dec. 31, 2010 $ 4,131,745 $ 11 $ 86,320 $ 254,915,713 $ (250,870,299)
Balance, shares at Dec. 31, 2010   11,000 86,319,913    
Issued restricted stock 872 0 872 0 0
Issued restricted stock, shares   0 872,000    
Cancelled restricted stock (596) 0 (686) 90 0
Cancelled restricted stock, shares   0 (686,000)    
Issued stock upon exercise of stock options, net (2,498,223) 0 1,832 (2,500,055) 0
Issued stock upon exercise of stock options, net, shares 1,832,673 0 1,832,673    
Issued stock to 401(k) plan 61,971 0 35 61,936 0
Issued stock to 401(k) plan, shares 35,233 0 35,233    
Issued stock upon exercise of warrants, net 8,327,190 0 4,027 8,323,163 0
Issued stock upon exercise of warrants, net, shares   0 4,026,552    
Conversion of Series B preferred stock to common stock 0 (1) 2,999 (2,998) 0
Conversion of Series B preferred stock to common stock, shares   (917) 2,998,590    
Effect of change in terms of warrants 1,978,818 0 0 1,978,818 0
Effect of beneficial conversion feature of promissory note 24,888 0 0 24,888 0
Stock compensation expense 3,592,090 0 0 3,592,090 0
Preferred stock dividends (100,000) 0 0 0 (100,000)
Net (loss) income 5,612,992 0 0 0 5,612,992
Balance at Dec. 31, 2011 21,131,747 10 95,399 266,393,645 (245,357,307)
Balance, shares at Dec. 31, 2011   10,083 95,398,961    
Issued restricted stock 455 0 455 0 0
Issued restricted stock, shares   0 455,000    
Cancelled restricted stock (596) 0 (601) 5 0
Cancelled restricted stock, shares   0 (600,500)    
Issued stock upon exercise of stock options, net 743,295 0 1,226 742,069 0
Issued stock upon exercise of stock options, net, shares 1,225,271 0 1,225,271    
Cancelled stock to pay employee tax obligations (100,875) 0 (37) (100,838) 0
Cancelled stock to pay employee tax obligations, shares   0 (37,500)    
Issued stock to 401(k) plan 50,272 0 17 50,255 0
Issued stock to 401(k) plan, shares 17,390 0 17,390    
Issued stock for payment of sublicense fee 1,146,000 0 300 1,145,700 0
Issued stock for payment of sublicense fee, shares 300,000 0 300,000    
Issued stock upon exercise of warrants, net 1,978,601 0 6,020 1,972,581 0
Issued stock upon exercise of warrants, net, shares   0 6,020,000    
Conversion of Series B preferred stock to common stock 0 (2) 7,014 (7,012) 0
Conversion of Series B preferred stock to common stock, shares   (2,145) 7,014,150    
Conversion of Series C preferred stock to common stock 0 (1) 3,226 (3,225) 0
Conversion of Series C preferred stock to common stock, shares   (1,000) 3,226,000    
Effect of change in terms of warrants 496,671 0 0 496,671 0
Short-swing profit returned to the Company 45,473 0 0 45,473 0
Stock compensation expense 2,304,118 0 0 2,304,118 0
Preferred stock dividends (43,333) 0 0 0 (43,333)
Net (loss) income (29,157,204) 0 0 0 (29,157,204)
Balance at Dec. 31, 2012 (1,405,376) 7 113,019 273,039,442 (274,557,844)
Balance, shares at Dec. 31, 2012   6,938 113,018,772    
Issued restricted stock 74   74    
Issued restricted stock, shares     73,500    
Cancelled restricted stock (29)   (29)    
Cancelled restricted stock, shares     (29,250)    
Issued stock upon exercise of stock options, net (9,161)   40 (9,201)  
Issued stock upon exercise of stock options, net, shares 39,649   39,649    
Cancelled stock to pay employee tax obligations (610,556)   (194) (610,362)  
Cancelled stock to pay employee tax obligations, shares     (194,077)    
Issued stock to 401(k) plan 66,777 0 22 66,755  
Issued stock to 401(k) plan, shares 22,126 0 22,126    
Issued stock upon exercise of warrants, net 6,161,332 2 3,000 6,158,330  
Issued stock upon exercise of warrants, net, shares   2,365 3,000,000    
Conversion of Series B preferred stock to common stock 0 (1) 5,682 (5,681)  
Conversion of Series B preferred stock to common stock, shares   (1,738) 5,682,933    
Issued stock for payment of milestone fee 166,000   100 165,900  
Issued stock for payment of milestone fee, shares 100,000   100,000    
Issued warrants in connection with debt issuance 967,115     967,115  
Issued warrants in connection with public offering (7,686,046)     (7,686,046)  
Issued stock in connection with public offerings, net of costs 38,131,472   14,205 38,117,267  
Issued stock in connection with public offerings, net of costs, shares     14,205,770    
Stock compensation expense 2,908,269     2,908,269  
Net (loss) income (42,699,458)       (42,699,458)
Balance at Dec. 31, 2013 $ (4,009,587) $ 8 $ 135,919 $ 313,111,788 $ (317,257,302)
Balance, shares at Dec. 31, 2013   7,565 135,919,423