Quarterly report pursuant to Section 13 or 15(d)

Note 11 - Commitments and Contingencies (Details Textual)

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Note 11 - Commitments and Contingencies (Details Textual) - USD ($)
1 Months Ended
Apr. 12, 2018
Apr. 09, 2018
Mar. 26, 2018
Jan. 16, 2018
Nov. 02, 2017
Mar. 31, 2017
Mar. 03, 2017
Dec. 31, 2017
Mar. 31, 2017
CRG [Member] | Subsequent Event [Member]                  
Draws on Letter of Credit   $ 7,100,000              
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                  
Loss Contingency, Damages Awarded, Value, Additional Amount             $ 7,000,000 $ 7,000,000  
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration       $ 4,100,000       4,100,000  
Loss Contingency, Damages Awarded,Value, Requested Modified Amount       2,900,000          
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member] | Surety Bond [Member]                  
Loss Contingency, Amount Awarded to Other Party     $ 7,700,000            
CRG Loan Agreement, Texas Case [Member] | Pending Litigation [Member]                  
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration       4,100,000          
Loss Contingency, Damages Awarded,Value, Requested Modified Amount       $ 2,900,000          
CRG Loan Agreement, Ohio Case [Member] | Pending Litigation [Member] | Subsequent Event [Member]                  
Loss Contingency, Damages Sought, Value $ 4,100,000                
Platinum-Montaur Life Sciences LLC Litigation [Member] | Pending Litigation [Member]                  
Loss Contingency, Damages Sought, Value         $ 1,900,000        
Maximum [Member] | CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                  
Loss Contingency, Damages Awarded, Value             66,000,000 $ 66,000,000  
CRG [Member] | Term Loan Agreement [Member] | CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                  
Repayments of Debt           $ 59,000,000 59,000,000   $ 59,000,000
CRG [Member] | Term Loan Agreement [Member] | Maximum [Member]                  
Debt Instrument, Agreed-upon Final Payoff Amount             $ 66,000,000