Quarterly report pursuant to Section 13 or 15(d)

Note 16 - Supplemental Disclosure for Statements of Cash Flows (Details Textual)

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Note 16 - Supplemental Disclosure for Statements of Cash Flows (Details Textual) - USD ($)
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Mar. 31, 2017
Interest Paid, Excluding Capitalized Interest, Operating Activities $ 4,000 $ 7,400,000  
Stock Issued During Period, Shares, Employee Benefit Plan 94,684 105,308  
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution $ 35,980 $ 53,707  
Series NN Warrants [Member] | UCSD [Member]      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   1,000,000 1,000,000
Class of Warrant or Right, Grants in Period, Estimated Fair Value   $ 334,000