Note 15 - Segments - Segment Information (Details) - USD ($) |
3 Months Ended | 9 Months Ended | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sep. 30, 2018 |
Sep. 30, 2017 |
Sep. 30, 2018 |
Sep. 30, 2017 |
Dec. 31, 2017 |
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Revenue from contract with customer | $ 22,000 | $ 287,000 | |||||||||||||||
Grant and other revenue | 209,146 | $ 223,669 | 762,549 | $ 1,315,298 | |||||||||||||
Revenue | 231,458 | 223,669 | 1,050,030 | 1,415,298 | |||||||||||||
Cost of revenue | 38,101 | 73,811 | |||||||||||||||
Research and development expenses | 1,225,770 | 874,547 | 3,367,444 | 2,765,695 | |||||||||||||
Selling, general and administrative expenses, excluding depreciation and amortization | [1] | 2,651,113 | 1,684,381 | 6,141,386 | 8,809,070 | ||||||||||||
Depreciation, Depletion and Amortization, Nonproduction, Total | [2] | 37,590 | 50,326 | 113,088 | 197,655 | ||||||||||||
Loss from operations | (3,721,116) | [3] | (2,385,585) | (8,645,699) | [3] | (10,357,122) | [3] | ||||||||||
Other expense | (24,534) | [4] | 69,071 | (4,284,014) | [4] | (1,061,190) | [4] | ||||||||||
Income tax expense | (76,259) | 775,750 | (65,330) | 3,861,156 | |||||||||||||
Net loss from continuing operations | (3,821,909) | (1,540,764) | (12,995,043) | (7,557,156) | |||||||||||||
Net income (loss) | (3,821,909) | (1,389,488) | (12,953,928) | 79,004,006 | |||||||||||||
Total assets, net of depreciation and amortization | 9,109,042 | 9,109,042 | $ 20,781,436 | ||||||||||||||
Capital expenditures | 16,152 | 23,247 | 19,317 | 31,417 | |||||||||||||
Other income | (24,534) | [4] | 69,071 | (4,284,014) | [4] | (1,061,190) | [4] | ||||||||||
(Loss) income from discontinued operations | 5,399 | (1,938) | (332,838) | ||||||||||||||
Gain on sale of discontinued operations, net of tax | 145,877 | 43,053 | 86,894,000 | ||||||||||||||
Net loss | (3,821,909) | (1,389,488) | (12,953,928) | 79,004,006 | |||||||||||||
UNITED STATES | |||||||||||||||||
Total assets, net of depreciation and amortization | 9,089,645 | 22,521,506 | 9,089,645 | 22,521,506 | |||||||||||||
Non-US [Member] | |||||||||||||||||
Total assets, net of depreciation and amortization | 19,397 | 84,201 | 19,397 | 84,201 | |||||||||||||
Royalty [Member] | |||||||||||||||||
Revenue from contract with customer | 2,382 | 9,842 | |||||||||||||||
License [Member] | |||||||||||||||||
Revenue from contract with customer | 19,930 | 277,639 | 100,000 | ||||||||||||||
Diagnostics Segment [Member] | |||||||||||||||||
Grant and other revenue | 65,505 | 210,479 | 454,830 | 1,200,216 | |||||||||||||
Revenue | 87,817 | 742,311 | 1,300,216 | ||||||||||||||
Cost of revenue | 38,101 | 73,811 | |||||||||||||||
Research and development expenses | 711,355 | 734,539 | 2,409,524 | 2,255,842 | |||||||||||||
Selling, general and administrative expenses, excluding depreciation and amortization | [1] | ||||||||||||||||
Depreciation, Depletion and Amortization, Nonproduction, Total | [2] | ||||||||||||||||
Loss from operations | (661,639) | [3] | (524,060) | (1,741,024) | [3] | (955,626) | [3] | ||||||||||
Other expense | [4] | [4] | [4] | ||||||||||||||
Income tax expense | (10,081) | 175,496 | (8,797) | 323,149 | |||||||||||||
Net loss from continuing operations | (671,720) | (348,564) | (1,749,821) | (632,477) | |||||||||||||
Net income (loss) | (671,720) | (197,288) | (1,708,706) | 85,928,685 | |||||||||||||
Capital expenditures | |||||||||||||||||
Other income | [4] | [4] | [4] | ||||||||||||||
(Loss) income from discontinued operations | 5,399 | (1,938) | (332,838) | ||||||||||||||
Gain on sale of discontinued operations, net of tax | 145,877 | 43,053 | 86,894,000 | ||||||||||||||
Net loss | (671,720) | (197,288) | (1,708,706) | 85,928,685 | |||||||||||||
Diagnostics Segment [Member] | UNITED STATES | |||||||||||||||||
Total assets, net of depreciation and amortization | 117,722 | 14,675,489 | 117,722 | 14,675,489 | |||||||||||||
Diagnostics Segment [Member] | Non-US [Member] | |||||||||||||||||
Total assets, net of depreciation and amortization | 18,239 | 82,334 | 18,239 | 82,334 | |||||||||||||
Diagnostics Segment [Member] | Royalty [Member] | |||||||||||||||||
Revenue from contract with customer | 2,382 | 9,842 | |||||||||||||||
Diagnostics Segment [Member] | License [Member] | |||||||||||||||||
Revenue from contract with customer | 19,930 | 277,639 | 100,000 | ||||||||||||||
Therapeutics Segment [Member] | |||||||||||||||||
Grant and other revenue | 143,641 | 13,190 | 307,719 | 115,082 | |||||||||||||
Revenue | 143,641 | 307,719 | 115,082 | ||||||||||||||
Cost of revenue | |||||||||||||||||
Research and development expenses | 514,415 | 140,008 | 957,920 | 509,853 | |||||||||||||
Selling, general and administrative expenses, excluding depreciation and amortization | [1] | 20,532 | 13,359 | 45,769 | 19,342 | ||||||||||||
Depreciation, Depletion and Amortization, Nonproduction, Total | [2] | ||||||||||||||||
Loss from operations | (391,306) | [3] | (140,177) | (695,970) | [3] | (414,113) | [3] | ||||||||||
Other expense | [4] | [4] | [4] | ||||||||||||||
Income tax expense | (3,879) | 46,942 | (3,517) | 140,034 | |||||||||||||
Net loss from continuing operations | (395,185) | (93,235) | (699,487) | (274,079) | |||||||||||||
Net income (loss) | (395,185) | (93,235) | (699,487) | (274,079) | |||||||||||||
Capital expenditures | |||||||||||||||||
Other income | [4] | [4] | [4] | ||||||||||||||
(Loss) income from discontinued operations | |||||||||||||||||
Gain on sale of discontinued operations, net of tax | |||||||||||||||||
Net loss | (395,185) | (93,235) | (699,487) | (274,079) | |||||||||||||
Therapeutics Segment [Member] | UNITED STATES | |||||||||||||||||
Total assets, net of depreciation and amortization | 72,622 | 10,591 | 72,622 | 10,591 | |||||||||||||
Therapeutics Segment [Member] | Non-US [Member] | |||||||||||||||||
Total assets, net of depreciation and amortization | |||||||||||||||||
Therapeutics Segment [Member] | Royalty [Member] | |||||||||||||||||
Revenue from contract with customer | |||||||||||||||||
Therapeutics Segment [Member] | License [Member] | |||||||||||||||||
Revenue from contract with customer | |||||||||||||||||
Corporate Segment [Member] | |||||||||||||||||
Grant and other revenue | |||||||||||||||||
Revenue | |||||||||||||||||
Cost of revenue | |||||||||||||||||
Research and development expenses | |||||||||||||||||
Selling, general and administrative expenses, excluding depreciation and amortization | [1] | 2,630,581 | 1,671,022 | 6,095,617 | 8,789,728 | ||||||||||||
Depreciation, Depletion and Amortization, Nonproduction, Total | [2] | 37,590 | 50,326 | 113,088 | 197,655 | ||||||||||||
Loss from operations | (2,668,171) | [3] | (1,721,348) | (6,208,705) | [3] | (8,987,383) | [3] | ||||||||||
Other expense | (24,534) | [4] | 69,071 | (4,284,014) | [4] | (1,061,190) | [4] | ||||||||||
Income tax expense | (62,299) | 553,312 | (53,017) | 3,397,972 | |||||||||||||
Net loss from continuing operations | (2,755,004) | (1,098,965) | (10,545,736) | (6,650,601) | |||||||||||||
Net income (loss) | (2,755,004) | (1,098,965) | (10,545,736) | (6,650,601) | |||||||||||||
Capital expenditures | 16,152 | 23,247 | 19,317 | 31,417 | |||||||||||||
Other income | (24,534) | [4] | 69,071 | (4,284,014) | [4] | (1,061,190) | [4] | ||||||||||
(Loss) income from discontinued operations | |||||||||||||||||
Gain on sale of discontinued operations, net of tax | |||||||||||||||||
Net loss | (2,755,004) | (1,098,965) | (10,545,736) | (6,650,601) | |||||||||||||
Corporate Segment [Member] | UNITED STATES | |||||||||||||||||
Total assets, net of depreciation and amortization | 8,899,301 | 7,835,426 | 8,899,301 | 7,835,426 | |||||||||||||
Corporate Segment [Member] | Non-US [Member] | |||||||||||||||||
Total assets, net of depreciation and amortization | 1,158 | $ 1,867 | 1,158 | 1,867 | |||||||||||||
Corporate Segment [Member] | Royalty [Member] | |||||||||||||||||
Revenue from contract with customer | |||||||||||||||||
Corporate Segment [Member] | License [Member] | |||||||||||||||||
Revenue from contract with customer | |||||||||||||||||
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