Annual report pursuant to Section 13 and 15(d)

Cover
- Document And Entity Information
Financial Statements
Notes to Financial Statements
Accounting Policies
- Significant Accounting Policies (Policies)
Notes Tables
Notes Details

Note 21 - Supplemental Disclosure for Statements of Cash Flows (Details Textual)

v3.19.1

Note 21 - Supplemental Disclosure for Statements of Cash Flows (Details Textual) - USD ($)		1 Months Ended			12 Months Ended
	Nov. 20, 2018	Nov. 30, 2018	Mar. 31, 2017	Jan. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Nov. 30, 2017	Mar. 03, 2017
Interest Paid, Excluding Capitalized Interest, Operating Activities					$ 8,000	$ 7,400,000
Stock Issued During Period, Shares, Employee Benefit Plan					94,684	105,308
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution					$ 35,980	$ 53,707
Reclassification of Funds Invested				$ 200,000		200,000
Stock Issued During Period, Value, New Issues					3,000,000
Gain (Loss) on Extinguishment of Debt, Total					$ (5,291,616)	$ (4,201,668)
Common Stock [Member]
Stock Issued During Period, Shares, Employee Benefit Plan					94,684	105,308
Reclassification of Funds Invested
Stock Issued During Period, Shares, New Issues					18,320,610
Stock Issued During Period, Value, New Issues					$ 18,321
Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues	18,500,000	18,500,000
Platinum Loan Agreement [Member] \| Former Chief Executive Officer and President [Member]
Repayments of Convertible Debt		$ 2,200,000
Gain (Loss) on Extinguishment of Debt, Total		$ (1,000,000)
Platinum Loan Agreement [Member] \| Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Debt Conversion, Converted Instrument, Shares Issued		16,400,000
Stock Issued During Period, Value, New Issues		$ 3,200,000
IPFS [Member] \| Notes Payable Issued for Prepayment of Insurance Premiums [Member]
Debt Instrument, Face Amount		$ 393,000					$ 396,000
Debt Instrument, Interest Rate, Stated Percentage		5.10%					4.00%
Series NN Warrants [Member] \| UCSD [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights			1,000,000			1,000,000		1,000,000
Class of Warrant or Right, Grants in Period, Estimated Fair Value			$ 334,000			$ 334,000

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