Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' Deficit

Consolidated Statements of Stockholders' Deficit - USD ($)	Total	Series B Preferred Stock [Member]	Preferred Stock [Member]	Preferred Stock [Member] Series B Preferred Stock [Member]	Common Stock [Member]	Common Stock [Member] Series B Preferred Stock [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] Series B Preferred Stock [Member]	Accumulated Deficit [Member]	Non-controlling Interest [Member]
Balance at Dec. 31, 2012	$ (1,405,376)		$ 7		$ 113,019		$ 273,039,442		$ (274,557,844)
Balance, shares at Dec. 31, 2012			6,938		113,018,772
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issued stock in connection with public offerings, net of costs	38,131,472				$ 14,205		38,117,267
Issued stock in connection with public offerings, net of costs, shares					14,205,770
Issued stock upon exercise of stock options, net	$ (9,161)				$ 40		(9,201)
Issued stock upon exercise of stock options, net, shares	39,649				39,649
Issued restricted stock	$ 74				$ 74
Issued restricted stock, shares					73,500
Canceled stock to pay employee tax obligations	(610,556)				$ (194)		(610,362)
Canceled stock to pay employee tax obligations, shares					(194,077)
Canceled forfeited restricted stock	(29)				$ (29)
Canceled forfeited restricted stock, shares					(29,250)
Issued stock upon exercise of warrants, net	6,161,332		$ 2		$ 3,000		6,158,330
Issued stock upon exercise of warrants, net, shares			2,365		3,000,000
Issued stock to 401(k) plan	$ 66,777				$ 22		66,755
Issued stock to 401(k) plan, shares	22,126				22,126
Issued stock for payment of milestone fee	$ 166,000				$ 100		165,900
Issued stock for payment of milestone fee, shares	100,000				100,000
Conversion of Series B preferred stock to common stock, net				$ (1)		$ 5,682		$ (5,681)
Conversion of Series B preferred stock to common stock, shares		2,364.9		(1,738)		5,682,933
Issued warrants in connection with debt issuance	$ 967,115						967,115
Issued warrants in connection with public offering	(7,686,046)						(7,686,046)
Stock compensation expense	2,908,269						2,908,269
Net loss	(42,699,458)								(42,699,458)
Balance at Dec. 31, 2013	(4,009,587)		$ 8		$ 135,919		313,111,788		(317,257,302)
Balance, shares at Dec. 31, 2013			7,565		135,919,423
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issued stock upon exercise of stock options, net	$ (51,369)				$ 300		(51,669)
Issued stock upon exercise of stock options, net, shares	299,360				299,360
Issued restricted stock	$ 380				$ 380
Issued restricted stock, shares					380,250
Canceled stock to pay employee tax obligations	(8,819)				$ (6)		(8,813)
Canceled stock to pay employee tax obligations, shares					(6,582)
Canceled forfeited restricted stock	(300)				$ (300)
Canceled forfeited restricted stock, shares					(300,000)
Issued stock upon exercise of warrants, net	7,686,773				$ 3,843		7,682,930
Issued stock upon exercise of warrants, net, shares					3,843,223
Issued stock to 401(k) plan	$ 100,043				$ 36		100,007
Issued stock to 401(k) plan, shares	36,455				36,455
Conversion of Series B preferred stock to common stock, net				$ (4)		$ 9,960		(9,956)
Conversion of Series B preferred stock to common stock, shares				(3,046)		9,960,420
Issued warrants in connection with debt issuance	$ 464,991						464,991
Issued stock in payment of Board retainers	89,375				$ 68		89,307
Issued stock in payment of Board retainers, shares					67,710
Recovery of shareholder short swing profits	17,554						17,554
Stock compensation expense	1,634,162						1,634,162
Net loss	(35,726,669)								(35,726,669)
Balance at Dec. 31, 2014	(29,803,466)		$ 4		$ 150,200		323,030,301		(352,983,971)
Balance, shares at Dec. 31, 2014			4,519		150,200,259
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issued stock upon exercise of stock options, net	$ 54,330				$ 124		54,206
Issued stock upon exercise of stock options, net, shares	124,238				124,238
Issued restricted stock	$ 354				$ 354
Issued restricted stock, shares					354,000
Canceled stock to pay employee tax obligations	(12,614)				$ (7)		(12,607)
Canceled stock to pay employee tax obligations, shares					(7,645)
Canceled forfeited restricted stock					$ (158)		158
Canceled forfeited restricted stock, shares					(158,000)
Issued stock upon exercise of warrants, net					$ 4,978		(4,978)
Issued stock upon exercise of warrants, net, shares					4,977,679
Issued stock to 401(k) plan	$ 117,099				$ 68		117,031
Issued stock to 401(k) plan, shares	68,157				68,157
Issued stock in payment of Board retainers	$ 172,969				$ 91		172,878
Issued stock in payment of Board retainers, shares					90,977
Exchanged Series B Preferred Stock for warrants				$ (4)				$ 4
Exchanged Series B Preferred Stock for warrants, shares				(4,519)
Extension of warrant expiration date	149,615						149,615
Issued warrants in connection with advisory services agreement	256,450						256,450
Stock compensation expense	2,368,685						2,368,685
Net loss	(27,563,535)								(27,562,680)	$ (855)
Balance at Dec. 31, 2015	(53,835,700)		$ 0		$ 155,650		326,085,743		$ (380,546,651)	469,558
Balance, shares at Dec. 31, 2015					155,649,665
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of MT Preferred Stock, net of deemed dividend	$ 424,413						$ (46,000)			$ 470,413