Annual report pursuant to Section 13 and 15(d)

Income Taxes (Schedule of Tax Rate Reconciliation) (Details)

v3.3.1.900
Income Taxes (Schedule of Tax Rate Reconciliation) (Details) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Amount      
Benefit at statutory rate $ (9,777,786) $ (12,147,068) $ (14,517,816)
Adjustments to valuation allowance 9,728,667 12,925,380 15,399,021
Adjustments to R&D credit carryforwards (612,087) (340,886) (842,414)
Disqualified debt interest 438,007    
Permanent items and other (212,852) $ (437,426) $ (38,791)
Benefit per financial statements $ (436,051)    
Percent      
Benefit at statutory rate (34.00%) (34.00%) (34.00%)
Adjustments to valuation allowance 33.80% 36.20% 36.10%
Adjustments to R&D credit carryforwards (2.10%) (1.00%) (2.00%)
Disqualified debt interest 1.50% 0.00% 0.00%
Permanent items and other (0.70%) (1.20%) (0.10%)