Quarterly report pursuant to Section 13 or 15(d)

Note 17 - Supplemental Disclosure for Statements of Cash Flows

Note 17 - Supplemental Disclosure for Statements of Cash Flows

9 Months Ended

Sep. 30, 2017

Notes to Financial Statements

Cash Flow, Supplemental Disclosures [Text Block]

Supplemental Disclosure for Statements of Cash Flows

During the

nine

-month periods ended

September 30, 2017

and

2016,

we paid interest aggregating

$7.4

million

$4.2

million, respectively. Interest paid during the

nine

-month period ended

September

30,

2016

includes collection fees of

$778,000

and a prepayment premium of

$2.1

million, both of which were withdrawn by CRG from a bank account under their control. During the

nine

-month period ended

September 30, 2017,

we issued

million Series NN warrants to UCSD with an estimated fair value of

$334,000.

As discussed in Note

the liability for the additional

$200,000

of investments made by Platinum was reclassified to additional paid-in-capital in

January 2017.

During the

nine

month-periods ended

September

30,

2017

and

2016,

we issued

105,308

and

67,002

shares of our common stock as matching contributions to our

401

(k) Plan, which were valued at

$53,707

and

$120,800,

respectively.