Note 15 - Segments - Segment Information (Details) - USD ($)
|
3 Months Ended |
9 Months Ended |
|
Sep. 30, 2019 |
Jun. 30, 2019 |
Mar. 31, 2019 |
Sep. 30, 2018 |
Jun. 30, 2018 |
Mar. 31, 2018 |
Sep. 30, 2019 |
Sep. 30, 2018 |
Dec. 31, 2018 |
Revenue from contract with customer |
|
$ 5,000
|
|
|
$ 22,000
|
|
|
$ 35,000
|
$ 303,000
|
|
Grant and other revenue |
|
231,916
|
|
|
209,146
|
|
|
514,589
|
762,549
|
|
Revenue |
|
236,811
|
|
|
231,458
|
|
|
538,527
|
1,050,030
|
|
Cost of revenue |
|
195
|
|
|
38,101
|
|
|
6,559
|
73,811
|
|
Research and development expenses |
|
1,801,558
|
|
|
1,225,770
|
|
|
3,612,783
|
3,367,444
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,485,207
|
|
|
2,651,113
|
|
|
5,001,818
|
6,141,386
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
34,289
|
|
|
37,590
|
|
|
107,794
|
113,088
|
|
(Loss) income from operations (3) |
[3] |
(3,084,438)
|
|
|
(3,721,116)
|
|
|
(8,190,427)
|
(8,645,699)
|
|
Other income (4) |
[4] |
10,334
|
|
|
(24,534)
|
|
|
17,456
|
(4,284,014)
|
|
Provision for income taxes |
|
|
|
|
(76,259)
|
|
|
(707)
|
(65,330)
|
|
Net (loss) income |
|
(3,074,104)
|
$ (2,673,179)
|
$ (2,429,061)
|
(3,821,909)
|
$ (2,394,057)
|
$ (6,737,962)
|
(8,176,343)
|
(12,953,928)
|
|
Total assets, net of depreciation and amortization |
|
4,821,656
|
|
|
|
|
|
4,821,656
|
|
$ 7,021,527
|
Capital expenditures |
|
|
|
|
16,152
|
|
|
|
19,317
|
|
Net income (loss) |
|
(3,074,104)
|
$ (2,673,179)
|
$ (2,429,061)
|
(3,821,909)
|
$ (2,394,057)
|
$ (6,737,962)
|
(8,176,343)
|
(12,953,928)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
(8,173,678)
|
(12,995,043)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
(2,665)
|
(1,938)
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
43,053
|
|
UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
4,819,050
|
|
|
9,089,645
|
|
|
4,819,050
|
9,089,645
|
|
Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
2,606
|
|
|
19,397
|
|
|
2,606
|
19,397
|
|
Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
4,895
|
|
|
2,382
|
|
|
13,985
|
9,842
|
|
License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
19,930
|
|
|
9,953
|
277,639
|
|
Diagnostics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
77,049
|
|
|
65,505
|
|
|
309,670
|
454,830
|
|
Revenue |
|
81,944
|
|
|
87,817
|
|
|
333,608
|
742,311
|
|
Cost of revenue |
|
195
|
|
|
38,101
|
|
|
6,559
|
73,811
|
|
Research and development expenses |
|
1,678,423
|
|
|
711,355
|
|
|
3,194,468
|
2,409,524
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
|
|
|
|
|
|
|
|
|
(Loss) income from operations (3) |
[3] |
(1,596,674)
|
|
|
(661,639)
|
|
|
(2,867,419)
|
(1,741,024)
|
|
Other income (4) |
[4] |
|
|
|
|
|
|
|
|
|
Provision for income taxes |
|
(72)
|
|
|
(10,081)
|
|
|
(248)
|
(8,797)
|
|
Net (loss) income |
|
(1,596,746)
|
|
|
(671,720)
|
|
|
(2,870,332)
|
(1,708,706)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
(1,596,746)
|
|
|
(671,720)
|
|
|
(2,870,332)
|
(1,708,706)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
(2,867,667)
|
(1,749,821)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
(2,665)
|
(1,938)
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
43,053
|
|
Diagnostics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
36,811
|
|
|
117,722
|
|
|
36,811
|
117,722
|
|
Diagnostics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
2,606
|
|
|
18,239
|
|
|
2,606
|
18,239
|
|
Diagnostics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
4,895
|
|
|
2,382
|
|
|
13,985
|
9,842
|
|
Diagnostics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
19,930
|
|
|
9,953
|
277,639
|
|
Therapeutics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
154,867
|
|
|
143,641
|
|
|
204,919
|
307,719
|
|
Revenue |
|
154,867
|
|
|
143,641
|
|
|
204,919
|
307,719
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
123,135
|
|
|
514,415
|
|
|
418,315
|
957,920
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,052
|
|
|
20,532
|
|
|
15,828
|
45,769
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
|
|
|
|
|
|
|
|
|
(Loss) income from operations (3) |
[3] |
30,680
|
|
|
(391,306)
|
|
|
(229,224)
|
(695,970)
|
|
Other income (4) |
[4] |
|
|
|
|
|
|
|
|
|
Provision for income taxes |
|
16
|
|
|
(3,879)
|
|
|
(20)
|
(3,517)
|
|
Net (loss) income |
|
30,696
|
|
|
(395,185)
|
|
|
(229,244)
|
(699,487)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
30,696
|
|
|
(395,185)
|
|
|
(229,244)
|
(699,487)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
(229,244)
|
(699,487)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
93,860
|
|
|
72,622
|
|
|
93,860
|
72,622
|
|
Therapeutics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] |
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
|
Revenue |
|
|
|
|
|
|
|
|
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
|
|
|
|
|
|
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,484,155
|
|
|
2,630,581
|
|
|
4,985,990
|
6,095,617
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
34,289
|
|
|
37,590
|
|
|
107,794
|
113,088
|
|
(Loss) income from operations (3) |
[3] |
(1,518,444)
|
|
|
(2,668,171)
|
|
|
(5,093,784)
|
(6,208,705)
|
|
Other income (4) |
[4] |
10,334
|
|
|
(24,534)
|
|
|
17,456
|
(4,284,014)
|
|
Provision for income taxes |
|
55
|
|
|
(62,299)
|
|
|
(439)
|
(53,017)
|
|
Net (loss) income |
|
(1,508,055)
|
|
|
(2,755,004)
|
|
|
(5,076,767)
|
(10,545,736)
|
|
Capital expenditures |
|
|
|
|
16,152
|
|
|
|
19,317
|
|
Net income (loss) |
|
(1,508,055)
|
|
|
(2,755,004)
|
|
|
(5,076,767)
|
(10,545,736)
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
(5,076,767)
|
(10,545,736)
|
|
Loss from discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
4,688,379
|
|
|
8,899,301
|
|
|
4,688,379
|
8,899,301
|
|
Corporate Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
1,158
|
|
|
|
1,158
|
|
Corporate Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
|
|