Annual report pursuant to Section 13 and 15(d)

Note 12 - Notes Payable (Details Textual)

Note 12 - Notes Payable (Details Textual) - USD ($)					1 Months Ended						12 Months Ended
Note 12 - Notes Payable (Details Textual) - USD ($)	Apr. 09, 2018	Mar. 31, 2017	Mar. 03, 2017	Jun. 22, 2016	Nov. 30, 2019	Nov. 30, 2018	Dec. 31, 2017	Nov. 30, 2017	Jun. 30, 2016	May 31, 2015	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2015	Jul. 31, 2012
Gain (Loss) on Extinguishment of Debt, Total												$ (5,291,616)
Interest Expense, Debt, Total											8,000	161,000
Notes Payable, Current, Total											305,955	316,074
Interest Expense Recorded Related to Amortization of Debt Discounts and Deferred Financing Costs											0	153,000
Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months											$ 306,000
CRG [Member]
Draws on Letter of Credit	$ 7,100,000
Judicial Ruling [Member] \| CRG Loan Agreement, Texas Case [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount			$ 7,000,000				$ 7,000,000
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration							4,100,000		$ 4,100,000
Maximum [Member] \| Judicial Ruling [Member] \| CRG Loan Agreement, Texas Case [Member]
Loss Contingency, Damages Awarded, Value							66,000,000
Common Stock [Member]
Stock Issued During Period, Shares, New Issues											8,000,000
Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues						925,000
Platinum Loan Agreement [Member]
Line of Credit Facility, Maximum Borrowing Capacity														$ 50,000,000
Platinum Loan Agreement [Member] \| Former Chief Executive Officer and President [Member]
Debt Conversion, Original Debt, Amount						$ 2,200,000
Gain (Loss) on Extinguishment of Debt, Total						$ (1,000,000)
Platinum Loan Agreement [Member] \| Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Debt Conversion, Converted Instrument, Shares Issued						817,857
Debt Conversion, Converted Instrument, Amount						$ 3,200,000
Platinum-Montaur Life Sciences LLC Litigation [Member]
Interest Expense, Debt, Excluding Amortization												153,000
Term Loan Agreement [Member] \| Judicial Ruling [Member] \| CRG Loan Agreement, Texas Case [Member]
Repayments of Debt	$ 7,100,000
Term Loan Agreement [Member] \| CRG [Member]
Interest Expense, Debt, Excluding Amortization													$ 1,800,000
Debt Instrument, Face Amount										$ 50,000,000
Debt Instrument, Interest Rate, Stated Percentage										14.00%
Percentage of Per Annum Interest Paying in Cash										10.00%
Percentage of Per Annum Interest as Compounded Interest										4.00%
Debt Instrument, Number of Quarterly Payments										8
Debt Instrument Payment Terms Payment Period										2 years
Debt Instrument, Interest Rate in the Event of Default										18.00%
Primary Bank Account Cash Taken Possession Of By Creditor				$ 4,100,000
Payments to Prepayment Premium and Backend Facility Fee on Claims of Default				3,900,000
Payments to Principal Balance of Debt on Claims of Default				$ 189,000
Repayments of Debt			59,000,000
Term Loan Agreement [Member] \| CRG [Member] \| Judicial Ruling [Member] \| CRG Loan Agreement, Texas Case [Member]
Repayments of Debt		$ 59,000,000	59,000,000
Term Loan Agreement [Member] \| CRG [Member] \| Maximum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount			$ 66,000,000				$ 66,000,000
Notes Payable Issued for Prepayment of Insurance Premiums [Member]
Notes Payable, Current, Total												316,000
Notes Payable Issued for Prepayment of Insurance Premiums [Member] \| IPFS [Member]
Debt Instrument, Face Amount					$ 349,000	$ 393,000		$ 396,000
Debt Instrument, Interest Rate, Stated Percentage					5.00%	5.10%		4.00%
Debt Instrument, Term						300 days		300 days
Debt Instrument, Periodic Payment, Total						$ 40,000		$ 40,000
Interest Expense, Debt, Total											$ 6,000	$ 8,000
Notes Payable Issued for Prepayment of Insurance Premiums [Member] \| FIF [Member]
Debt Instrument, Face Amount					$ 349,000
Debt Instrument, Interest Rate, Stated Percentage					5.00%
Debt Instrument, Term					240 days
Debt Instrument, Periodic Payment, Total					$ 44,000
Interest Expense, Debt, Total											1,000
Notes Payable, Current, Total											$ 306,000