Quarterly report pursuant to Section 13 or 15(d)

Note 11 - Equity (Details Textual)

v3.22.2.2
Note 11 - Equity (Details Textual)
 3 Months Ended 9 Months Ended
Sep. 09, 2022
Aug. 30, 2022
USD ($)
$ / shares
shares
Aug. 03, 2022
$ / shares
shares
Jul. 01, 2022
USD ($)
Apr. 10, 2022
USD ($)
shares
Apr. 07, 2022
shares
Sep. 30, 2022
USD ($)
shares
Mar. 31, 2022
USD ($)
shares
Jun. 30, 2021
USD ($)
shares
Mar. 31, 2021
USD ($)
shares
Sep. 30, 2022
USD ($)
shares
Sep. 30, 2021
USD ($)
shares
Jan. 31, 2022
USD ($)
shares
Dec. 31, 2021
USD ($)
Stockholders' Equity Attributable to Noncontrolling Interest, Ending Balance             $ 292,517       $ 292,517     $ 731,299
Additional Paid in Capital, Total             $ 379,337,227       $ 379,337,227     370,459,705
Operating Loss Carryforwards                           164,000,000
Share Purchase Right, Ownership Percentage Threshold           4.99%                
Share Purchase Right, Ownership Percentage Trigger           0.50%                
Share Purchase Right, Discount Percentage           50.00%                
Rights Offering, Shares Authorized (in shares) | shares     35,000                      
Shares Issued, Price Per Share (in dollars per share) | $ / shares     $ 1,000                      
Units Issued During Period, Units, New Issues (in shares) | shares   10,423                        
Proceeds from Issuance or Sale of Equity, Total   $ 6,173,000                        
Class of Warrant or Right, Outstanding (in shares) | shares             23,582,230       23,582,230      
Units Issued During Period, Value, New Issues   10,423,000                        
Stock Issued During Period, Value, New Issues             $ 19,740   $ 1,800,000          
Payments to Fund Clinical Research Trial   $ 963,270                        
Stock Issued During Period, Shares, Employee Benefit Plan (in shares) | shares                     53,238 30,018    
Stock Issued During Period, Value, Employee Benefit Plan               $ 44,720   $ 76,846 $ 44,720 $ 76,846    
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution                     44,720 $ 76,846    
LTIP [Member]                            
Stock Issued During Period, Value, New Issues                     $ 19,740      
Incentive Plan, Milestone, Percent, Step of Total Stock Award Payout 5.00%                          
Incentive Plan, Milestone, Percent, Regulatory Milestones 90.00%                          
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage 100.00%                          
Incentive Plan, Percent, Milestones Paid                     5.00%      
Stock Issued During Period, Shares, New Issues (in shares) | shares                     70,500      
Common Stock [Member]                            
Stock Issued During Period, Value, New Issues             $ 71   $ 0 $ 0        
Stock Issued During Period, Shares, Employee Benefit Plan (in shares) | shares               53,238   30,018        
Stock Issued During Period, Value, Employee Benefit Plan               $ 53   $ 30        
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares) | shares             28,150 16,632            
Stock Issued During Period, Shares, New Issues (in shares) | shares             70,500   0          
Employees [Member] | Common Stock [Member]                            
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares) | shares                     44,782      
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution                     $ 24,847      
John K. Scott, Jr. [Member]                            
Maximum Number of Units Purchasable (in shares) | shares   2,400                        
Unit Warrants [Member]                            
Class of Warrant or Right, Outstanding (in shares) | shares   1                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares   2,222                        
Class of Warrant or Right, Purchase Price of Stock (in dollars per share) | $ / shares   $ 0.45                        
Class of Warrants or Rights, Warrant Proceeds if Exercised   $ 11,600,000                        
Warrants and Rights Outstanding   $ 4,144,185                        
Unit Warrants [Member] | Measurement Input, Price Volatility [Member]                            
Warrants and Rights Outstanding, Measurement Input   0.8925                        
Unit Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                            
Warrants and Rights Outstanding, Measurement Input   0.0327                        
Unit Warrants [Member] | Measurement Input, Expected Dividend Payment [Member]                            
Warrants and Rights Outstanding, Measurement Input   0                        
Series E Preferred Stock Exchanged for Sereis F and G Preferred Stock [Member]                            
Conversion of Stock, Shares Converted (in shares) | shares         50,000                  
Series E Preferred Stock Exchanged for Sereis F Preferred Stock [Member]                            
Conversion of Stock, Shares Issued (in shares) | shares         1,740                  
Series E Preferred Stock Exchanged for Sereis G Preferred Stock [Member]                            
Conversion of Stock, Shares Issued (in shares) | shares         3,260                  
Units Sold in Exchange for Series D Preferred Stock [Member]                            
Units Issued During Period, Units, New Issues (in shares) | shares   4,250                        
Convertible Preferred Stock, Fair Value                     2,212,114      
Convertible Preferred Stock, Shares Issued Upon Conversion, Fair Value                     4,250,000      
Dividends, Preferred Stock, Total                     $ 2,037,886      
Bridge Loan [Member]                            
Debt Instrument, Face Amount         $ 2,500,000                  
Proceeds from Issuance of Long-Term Debt, Total       $ 1,000,000.0 $ 1,500,000                  
Debt Instrument, Interest Rate, Stated Percentage         8.00%                  
Debt Instrument, Term (Year)         2 years                  
MT [Member]                            
Ownership Percentage                         60.00%  
Stockholders' Equity Attributable to Noncontrolling Interest, Ending Balance                           $ 731,299
MT Preferred Stock [Member]                            
Preferred Stock, Stock Returned (in shares) | shares                         6  
Additional Paid in Capital, Total                         $ 438,778  
Series H Preferred Stock [Member]                            
Share Purchase Right, Shares Issuable Per Each Right (in shares) | shares           1,000                
Series I Preferred Stock [Member]                            
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares   2,222                        
Stock Issued During Period, Value, New Issues   $ 6,278,815         $ 5,209,735              
Series I Preferred Stock [Member] | Common Stock [Member]                            
Stock Issued During Period, Value, New Issues             $ 0              
Stock Issued During Period, Shares, New Issues (in shares) | shares             0