Annual report pursuant to Section 13 and 15(d)

Equity Instruments (Narrative) (Details)

v3.3.1.900
Equity Instruments (Narrative) (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Oct. 31, 2015
Sep. 30, 2015
Jul. 31, 2015
Jul. 30, 2015
Nov. 30, 2014
Jul. 31, 2014
Sep. 30, 2013
Jun. 30, 2013
Apr. 30, 2013
Mar. 31, 2013
Feb. 28, 2013
Sep. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Mar. 11, 2015
Mar. 31, 2014
Class Of Stock [Line Items]                                  
Issued stock in connection with public offerings, net of costs, shares             10,563,381   2,100,000   1,542,389            
Shares issued price per share             $ 2.84   $ 2.43   $ 3.10            
Proceeds from issuance of common stock net of issuance costs             $ 28,800,000   $ 4,800,000   $ 4,500,000            
Proceeds from issuance of common stock             30,000,000           $ 65,975 $ 87,984 $ 41,303,750    
Exercise price of warrant issued, dollars per share                         $ 0.38        
Warrants, expiration date                         Sep. 24, 2016        
Placement agent fees             $ 999,000                    
Placement agent fees as a percentage of gross proceeds             3.30%                    
Warrants outstanding                         11,677,700        
Warrants, weighted average exercise price                         $ 0.38        
Shares conversion, number of common stock equivalent to each preferred stock               3,270                  
Repayments of notes payable     $ 333,333     $ 666,666             $ 30,333,333 $ 25,000,000 $ 5,982,155    
Extension of warrant expiration date                         $ (149,615)        
Common stock reserved for future issuance                         24,365,285        
Series B Preferred Stock [Member]                                  
Class Of Stock [Line Items]                                  
Conversion of Series B preferred stock to common stock, shares               2,364.9             2,364.9    
Platinum Montaur Life Sciences Llc [Member]                                  
Class Of Stock [Line Items]                                  
Repayments of notes payable               $ 4,781,333             $ 4,800,000    
Common Stock [Member]                                  
Class Of Stock [Line Items]                                  
Issued stock in connection with public offerings, net of costs, shares                             14,205,770    
Issued stock upon exercise of warrants, net, shares         3,843,223               4,977,679 3,843,223 3,000,000    
Shares conversion, number of common stock equivalent to each preferred stock               3,270                  
Common Stock [Member] | Series B Preferred Stock [Member]                                  
Class Of Stock [Line Items]                                  
Conversion of Series B preferred stock to common stock, shares                           9,960,420 5,682,933    
Common Stock [Member] | Macrophage Therapeutics [Member]                                  
Class Of Stock [Line Items]                                  
Warrants, number of securities called by warrants                         300     300  
Exercise price of warrant issued, dollars per share                         $ 2,000        
Minimum [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                         0.01        
Maximum [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                         3.04        
Series JJ Warrants [Member]                                  
Class Of Stock [Line Items]                                  
Warrants, number of securities called by warrants             3,169,015                    
Exercise price of warrant issued, dollars per share             $ 3.83                    
Reclassification to additional paid in capital         $ 7,700,000                        
Series X Warrants [Member] | Platinum Montaur Life Sciences Llc [Member]                                  
Class Of Stock [Line Items]                                  
Warrants exercised                   3,000,000              
Issued stock upon exercise of warrants, net, shares                   3,000,000              
Proceeds from warrant exercises                   $ 1,380,000              
Series X Warrants And Series AA Warrants [Member] | Platinum Montaur Life Sciences Llc [Member]                                  
Class Of Stock [Line Items]                                  
Number of common shares underlying Series B Preferred Stock               7,733,223                  
Series HH Warrants [Member]                                  
Class Of Stock [Line Items]                                  
Warrants, number of securities called by warrants               301,205                  
Exercise price of warrant issued, dollars per share                         $ 2.49        
Warrants, expiration date                         Jun. 25, 2023        
Warrants outstanding                         301,205        
Series HH Warrants [Member] | General Electric Capital Corporation/MidCap Financial SBIC, LP [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share               $ 2.49                  
Series II Warrants [Member]                                  
Class Of Stock [Line Items]                                  
Warrants, number of securities called by warrants               275,000                  
Exercise price of warrant issued, dollars per share                         $ 3.04        
Warrants, expiration date                         Jun. 25, 2018        
Warrants outstanding                         275,000        
Class of warrant term               5 years                  
Series II Warrants [Member] | Maximum [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share               $ 3.04                  
Series KK warrants [Member}                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                         $ 1.918        
Warrants, expiration date                         Mar. 04, 2021        
Warrants outstanding                         391,032        
Series KK warrants [Member} | Oxford Finance, LLC [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                                 $ 1.918
Warrants outstanding                                 391,032
Series BB [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                         $ 2.00        
Warrants, expiration date                         Jul. 07, 2018        
Warrants outstanding                         300,000        
Warrant, outstanding extended term       3 years                          
Warrant, outstanding extended term, month and year       2018-07                          
Extension of warrant expiration date                       $ 150,000          
Series LL Warrants [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share                         $ 0.01        
Warrants, expiration date                         Aug. 31, 2035        
Warrants outstanding                         9,777,130        
Warrants exercised 5,000,000                                
Issued stock upon exercise of warrants, net, shares 4,977,679                                
Series MM warrants [Member] | Chardan Capital Markets, LLC [Member]                                  
Class Of Stock [Line Items]                                  
Exercise price of warrant issued, dollars per share $ 2.50 $ 2.50                   $ 2.50          
Number of warrants issued to purchase common stock   150,000                              
Common Stock Warrants Issuable 150,000                                
Issued warrants in connection with advisory services agreement                       $ 256,000          
Warrant, Outstanding Term 4 years 4 years