Quarterly report pursuant to Section 13 or 15(d)

Note 1 - Summary of Significant Accounting Policies (Details Textual)

v3.10.0.1
Note 1 - Summary of Significant Accounting Policies (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended
Mar. 31, 2017
Mar. 31, 2018
Jun. 30, 2017
Jun. 30, 2018
Jan. 01, 2018
Dec. 31, 2017
Notes Payable, Fair Value Disclosure       $ 2,200,000   $ 2,400,000
Notes Payable, Current, Total       2,200,353   2,353,639
Derivative Liability, Total       63,000   63,000
Deferred Revenue         $ 726,061  
Cumulative Effect of New Accounting Principle in Period of Adoption           (700,000)
Retained Earnings [Member]            
Cumulative Effect of New Accounting Principle in Period of Adoption           (700,000)
Accounting Standards Update 2014-09 [Member] | Retained Earnings [Member]            
Cumulative Effect of New Accounting Principle in Period of Adoption         (700,000)  
Accounting Standards Update 2014-09 [Member] | Sayre Pharmaceuticals [Member]            
Deferred Revenue         700,000  
Accounting Standards Update 2014-09 [Member] | Sayre Pharmaceuticals [Member] | Retained Earnings [Member]            
Cumulative Effect of New Accounting Principle in Period of Adoption         $ (100,000)  
Accounting Standards Update 2016-18 [Member] | Fiscal Year 2016 [Member]            
Prior Period Reclassification Adjustment   $ 5,000,000        
Series NN Warrants [Member]            
Class of Warrant or Right, Term 5 years          
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 1.50          
Series NN Warrants [Member] | Cardinal Health 414 [Member]            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 10,000,000          
Class of Warrant or Right, Grants in Period, Estimated Fair Value     $ 3,300,000      
Series NN Warrants [Member] | UCSD [Member]            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 1,000,000   1,000,000      
Class of Warrant or Right, Grants in Period, Estimated Fair Value     $ 334,000      
Former Executive [Member]            
Accounts Payable, Disputed       $ 96,000   $ 96,000