Note 15 - Segments - Segment Information (Details) - USD ($)
|
3 Months Ended |
6 Months Ended |
|
Jun. 30, 2018 |
Jun. 30, 2017 |
Jun. 30, 2018 |
Jun. 30, 2017 |
Dec. 31, 2017 |
Revenue from contract with customer |
|
$ 264,000
|
|
|
$ 265,000
|
|
|
|
|
Grant and other revenue |
|
277,753
|
|
$ 511,599
|
553,403
|
|
$ 1,091,629
|
|
|
Revenue |
|
542,127
|
|
611,599
|
818,572
|
|
1,191,629
|
|
|
Cost of revenue |
|
35,392
|
|
|
35,710
|
|
|
|
|
Research and development expenses |
|
1,142,718
|
|
1,185,874
|
2,141,674
|
|
1,891,148
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,751,888
|
|
4,179,045
|
3,490,273
|
|
7,124,689
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
37,511
|
|
70,539
|
75,498
|
|
147,329
|
|
|
Loss from operations |
[3] |
(2,425,382)
|
|
(4,823,859)
|
(4,924,583)
|
|
(7,971,537)
|
|
|
Other expense |
|
(20,719)
|
[4] |
40,848
|
(4,259,480)
|
[4] |
(1,130,261)
|
[4] |
|
Income tax benefit (expense) |
|
10,929
|
|
1,631,234
|
10,929
|
|
3,085,406
|
|
|
Net loss from continuing operations |
|
(2,435,172)
|
|
(3,151,777)
|
(9,173,134)
|
|
(6,016,392)
|
|
|
Loss from discontinued operations |
|
(1,938)
|
|
(82,376)
|
(1,938)
|
|
(338,237)
|
|
|
Gain on sale of discontinued operations, net of tax |
|
43,053
|
|
(1,953,378)
|
43,053
|
|
86,748,123
|
|
|
Net income (loss) |
|
(2,394,057)
|
|
(5,187,531)
|
(9,132,019)
|
|
80,393,494
|
|
|
Total assets, net of depreciation and amortization |
|
8,660,492
|
|
|
8,660,492
|
|
|
|
$ 20,781,436
|
Capital expenditures |
|
3,165
|
|
8,170
|
3,165
|
|
8,170
|
|
|
Other income |
|
(20,719)
|
[4] |
40,848
|
(4,259,480)
|
[4] |
(1,130,261)
|
[4] |
|
Net (loss) income from continuing operations |
|
(2,435,172)
|
|
(3,151,777)
|
(9,173,134)
|
|
(6,016,392)
|
|
|
Income tax benefit (expense) |
|
10,929
|
|
1,631,234
|
10,929
|
|
3,085,406
|
|
|
UNITED STATES |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
8,636,954
|
|
25,801,110
|
8,636,954
|
|
25,801,110
|
|
|
Non-US [Member] |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
23,538
|
|
101,105
|
23,538
|
|
101,105
|
|
|
Royalty [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
6,665
|
|
|
7,460
|
|
|
|
|
License [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
257,709
|
|
100,000
|
257,709
|
|
100,000
|
|
|
Diagnostics Segment [Member] |
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
156,889
|
|
418,375
|
389,325
|
|
989,737
|
|
|
Revenue |
|
421,263
|
|
518,375
|
654,494
|
|
1,089,737
|
|
|
Cost of revenue |
|
35,392
|
|
|
35,710
|
|
|
|
|
Research and development expenses |
|
913,158
|
|
1,108,101
|
1,698,169
|
|
1,521,303
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
|
|
|
|
|
|
|
|
Loss from operations |
[3] |
(527,287)
|
|
(589,726)
|
(1,079,385)
|
|
(431,566)
|
|
|
Other expense |
|
|
[4] |
|
|
[4] |
|
[4] |
|
Income tax benefit (expense) |
|
2,356
|
|
201,125
|
1,284
|
|
146,296
|
|
|
Net loss from continuing operations |
|
(524,931)
|
|
(388,601)
|
(1,078,101)
|
|
(285,270)
|
|
|
Loss from discontinued operations |
|
(1,938)
|
|
(82,376)
|
(1,938)
|
|
(338,237)
|
|
|
Gain on sale of discontinued operations, net of tax |
|
43,053
|
|
(1,953,378)
|
43,053
|
|
86,748,123
|
|
|
Net income (loss) |
|
(483,816)
|
|
(2,424,355)
|
(1,036,986)
|
|
86,124,616
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
Other income |
|
|
[4] |
|
|
[4] |
|
[4] |
|
Net (loss) income from continuing operations |
|
(524,931)
|
|
(388,601)
|
(1,078,101)
|
|
(285,270)
|
|
|
Income tax benefit (expense) |
|
2,356
|
|
201,125
|
1,284
|
|
146,296
|
|
|
Diagnostics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
409,769
|
|
16,373,919
|
409,769
|
|
16,373,919
|
|
|
Diagnostics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
22,147
|
|
98,806
|
22,147
|
|
98,806
|
|
|
Diagnostics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
6,665
|
|
|
7,460
|
|
|
|
|
Diagnostics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
257,709
|
|
100,000
|
257,709
|
|
100,000
|
|
|
Therapeutics Segment [Member] |
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
120,864
|
|
93,224
|
164,078
|
|
101,892
|
|
|
Revenue |
|
120,864
|
|
93,224
|
164,078
|
|
101,892
|
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
229,560
|
|
77,773
|
443,505
|
|
369,845
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
16,630
|
|
3,462
|
25,237
|
|
5,983
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
|
|
|
|
|
|
|
|
Loss from operations |
[3] |
(125,326)
|
|
11,989
|
(304,664)
|
|
(273,936)
|
|
|
Other expense |
|
|
[4] |
|
|
[4] |
|
[4] |
|
Income tax benefit (expense) |
|
560
|
|
(4,089)
|
363
|
|
92,861
|
|
|
Net loss from continuing operations |
|
(124,766)
|
|
7,900
|
(304,301)
|
|
(181,075)
|
|
|
Loss from discontinued operations |
|
|
|
|
|
|
|
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
(124,766)
|
|
7,900
|
(304,301)
|
|
(181,075)
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
Other income |
|
|
[4] |
|
|
[4] |
|
[4] |
|
Net (loss) income from continuing operations |
|
(124,766)
|
|
7,900
|
(304,301)
|
|
(181,075)
|
|
|
Income tax benefit (expense) |
|
560
|
|
(4,089)
|
363
|
|
92,861
|
|
|
Therapeutics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
87,751
|
|
16,002
|
87,751
|
|
16,002
|
|
|
Therapeutics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
Therapeutics Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] |
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
Revenue |
|
|
|
|
|
|
|
|
|
Cost of revenue |
|
|
|
|
|
|
|
|
|
Research and development expenses |
|
|
|
|
|
|
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
1,735,258
|
|
4,175,583
|
3,465,036
|
|
7,118,706
|
|
|
Depreciation, Depletion and Amortization, Nonproduction, Total |
[2] |
37,511
|
|
70,539
|
75,498
|
|
147,329
|
|
|
Loss from operations |
[3] |
(1,772,769)
|
|
(4,246,122)
|
(3,540,534)
|
|
(7,266,035)
|
|
|
Other expense |
|
(20,719)
|
[4] |
40,848
|
(4,259,480)
|
[4] |
(1,130,261)
|
[4] |
|
Income tax benefit (expense) |
|
8,013
|
|
1,434,198
|
9,282
|
|
2,846,249
|
|
|
Net loss from continuing operations |
|
(1,785,475)
|
|
(2,771,076)
|
(7,790,732)
|
|
(5,550,047)
|
|
|
Loss from discontinued operations |
|
|
|
|
|
|
|
|
|
Gain on sale of discontinued operations, net of tax |
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
(1,785,475)
|
|
(2,771,076)
|
(7,790,732)
|
|
(5,550,047)
|
|
|
Capital expenditures |
|
3,165
|
|
8,170
|
3,165
|
|
8,170
|
|
|
Other income |
|
(20,719)
|
[4] |
40,848
|
(4,259,480)
|
[4] |
(1,130,261)
|
[4] |
|
Net (loss) income from continuing operations |
|
(1,785,475)
|
|
(2,771,076)
|
(7,790,732)
|
|
(5,550,047)
|
|
|
Income tax benefit (expense) |
|
8,013
|
|
1,434,198
|
9,282
|
|
2,846,249
|
|
|
Corporate Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
8,139,434
|
|
9,411,189
|
8,139,434
|
|
9,411,189
|
|
|
Corporate Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
1,391
|
|
2,299
|
1,391
|
|
2,299
|
|
|
Corporate Segment [Member] | Royalty [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] | License [Member] |
|
|
|
|
|
|
|
|
|
Revenue from contract with customer |
|
|
|
|
|
|
|
|
|
|
|