Note 16 - Supplemental Disclosure for Statements of Cash Flows (Details Textual) - USD ($) |
6 Months Ended | ||
|---|---|---|---|
Jun. 30, 2018 |
Jun. 30, 2017 |
Mar. 31, 2017 |
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| Interest Paid, Excluding Capitalized Interest, Operating Activities | $ 4,000 | $ 7,400,000 | |
| Stock Issued During Period, Shares, Employee Benefit Plan | 94,684 | 105,308 | |
| Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution | $ 35,980 | $ 53,707 | |
| Series NN Warrants [Member] | UCSD [Member] | |||
| Class of Warrant or Right, Number of Securities Called by Warrants or Rights | 1,000,000 | 1,000,000 | |
| Class of Warrant or Right, Grants in Period, Estimated Fair Value | $ 334,000 | ||
| X | ||||||||||
- Definition Represents the estimated fair value of warrants or rights granted during the period. No definition available.
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| X | ||||||||||
- Definition Value of stock issued to the defined contribution plan for employer matching contribution. No definition available.
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| X | ||||||||||
- Definition Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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| X | ||||||||||
- Definition Amount of cash paid for interest, excluding capitalized interest, classified as operating activity. Includes, but is not limited to, payment to settle zero-coupon bond for accreted interest of debt discount and debt instrument with insignificant coupon interest rate in relation to effective interest rate of borrowing attributable to accreted interest of debt discount. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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| X | ||||||||||
- Definition Number of shares issued during the period to an employee benefit plan, such as a defined contribution or defined benefit plan. No definition available.
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