Quarterly report pursuant to Section 13 or 15(d)

Note 10 - Commitments and Contingencies (Details Textual)

Note 10 - Commitments and Contingencies (Details Textual) - USD ($)								1 Months Ended
	Mar. 15, 2023	Aug. 30, 2022	Apr. 08, 2022	Nov. 21, 2021	May 27, 2021	Apr. 09, 2018	Mar. 03, 2017	Nov. 30, 2018	Jun. 30, 2016	Mar. 31, 2023	Dec. 31, 2022	Oct. 11, 2022	Mar. 31, 2022	Dec. 31, 2021	Aug. 14, 2018
Equity, Including Portion Attributable to Noncontrolling Interest										$ (9,547,623)	$ (8,143,310)		$ (2,109,442)	$ 624,743
Common Stock [Member]
Equity, Including Portion Attributable to Noncontrolling Interest										223,848	$ 223,684		$ 221,354	$ 221,277
Former Chief Executive Officer and President [Member]
Common Stock Shares Provided by Agreement															1,175,000
Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues								925,000
Stock Issued During Period, Shares, New Issues Placed in Escrow								250,000
Former Chief Executive Officer and President [Member] \| Dr. Michael Goldberg [Member] \| MT [Member] \| Common Stock [Member]
Ownership Percentage															5.00%
CRG [Member]
Draws on Letter of Credit						$ 7,153,000
CRG Loan Agreement, Texas Case [Member]
Litigation Settlement, Attorneys’ Fees				$ 2,800,000
Litigation Settlement, Amount Awarded to Other Party		$ 2,600,000
Loss Contingencies, Interest Rate												18.00%
Loss Contingency Accrual										$ 3,500,011
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount							$ 7,000,000.0
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration						$ 4,200,000			$ 4,100,000
New York Litigation Involving Former CEO and President [Member] \| Judicial Ruling [Member]
Litigation Settlement, Amount Awarded to Other Party	$ 12,600
Litigation Settlement, Amount Can Be Awarded to Other Party for Indemnification for Attorneys’ Fees					$ 14,955
Litigation Settlement, Amount Can Be Advanced to Other Party for Attorneys’ Fees Subject to Repayment					$ 1,237
Litigation Settlement, Advancement for Attorney's Fees and Disbursements			$ 143,172
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Repayments of Debt							59,000,000.0
CRG [Member] \| Term Loan Agreement [Member] \| Maximum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount							$ 66,000,000.0