Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' (Deficit) Equity

Consolidated Statements of Stockholders' (Deficit) Equity - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	AOCI Attributable to Parent [Member]	Noncontrolling Interest [Member]	Total
Balance (in shares) at Dec. 31, 2016	155,762,729
Balance at Dec. 31, 2016	$ 155,763	$ 326,564,148	$ (394,855,034)		$ 468,910	$ (67,666,213)
Issued stock in payment of Board retainers (in shares)	16,406
Stock Issued During Period, Value, Issued for Services	$ 17	10,483				10,500
Issued stock in payment of employee bonuses (in shares)	710,353
Issued stock in payment of employee bonuses	$ 710	368,632				369,342
Issued stock upon exercise of warrants (in shares)	5,411,850
Issued stock upon exercise of warrants	$ 5,412	48,707				54,119
Issued warrants in connection with Asset Sale		3,337,187				3,337,187
Issued warrants for extension of license agreement		333,719				$ 333,719
Issued stock to 401(k) plan (in shares)	105,308					105,308
Issued stock to 401(k) plan	$ 105	53,602				$ 53,707
Issued restricted stock (in shares)	200,000
Issued restricted stock	$ 200					200
Canceled forfeited restricted stock (in shares)	(50,000)
Canceled forfeited restricted stock	$ (50)	50
Issued stock upon exercise of stock options (in shares)	50,000					50,000
Issued stock upon exercise of stock options	$ 50	18,050				$ 18,100
Stock compensation expense		394,209				394,209
Net income (loss)			74,946,066		(210)	74,945,856
Unrealized gain (loss) on available-for-sale securities				(2,396)		(2,396)
Total comprehensive income (loss)						74,943,460
Reclassification of funds invested (Note 10)					200,000	200,000
Balance (in shares) at Dec. 31, 2017	162,206,646
Balance at Dec. 31, 2017	$ 162,207	331,128,787	(319,908,968)	(2,396)	668,700	12,048,330
Issued stock in payment of employee bonuses (in shares)	1,118,760
Issued stock in payment of employee bonuses	$ 1,118	315,784				$ 316,902
Issued stock to 401(k) plan (in shares)	94,684					94,684
Issued stock to 401(k) plan	$ 95	35,885				$ 35,980
Issued restricted stock (in shares)	200,000
Issued restricted stock	$ 200					200
Canceled forfeited restricted stock (in shares)	(50,000)
Canceled forfeited restricted stock	$ (50)	50
Issued stock upon exercise of stock options (in shares)
Stock compensation expense		306,698				$ 306,698
Net income (loss)			(16,113,937)		(379)	(16,114,316)
Unrealized gain (loss) on available-for-sale securities				1,666		1,666
Total comprehensive income (loss)						(16,112,650)
Impact of adoption of ASC Topic 606 at Dec. 31, 2017			(700,000)			(700,000)
Issued stock pursuant to private placement (in shares)	18,320,610
Issued stock pursuant to private placement	$ 18,321	2,981,679				3,000,000
Issued stock pursuant to termination agreement (in shares)	18,500,000
Issued stock pursuant to termination agreement	$ 18,500	3,496,500				3,515,000
Balance (in shares) at Dec. 31, 2018	200,390,700
Balance at Dec. 31, 2018	$ 200,391	$ 338,265,383	$ (336,722,905)	$ (730)	$ 668,321	$ 2,410,460