Annual report pursuant to Section 13 and 15(d)

Note 21 - Supplemental Disclosure for Statements of Cash Flows (Details Textual)

v3.19.1
Note 21 - Supplemental Disclosure for Statements of Cash Flows (Details Textual) - USD ($)
1 Months Ended 12 Months Ended
Nov. 20, 2018
Nov. 30, 2018
Mar. 31, 2017
Jan. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Nov. 30, 2017
Mar. 03, 2017
Interest Paid, Excluding Capitalized Interest, Operating Activities         $ 8,000 $ 7,400,000    
Stock Issued During Period, Shares, Employee Benefit Plan         94,684 105,308    
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution         $ 35,980 $ 53,707    
Reclassification of Funds Invested       $ 200,000   200,000    
Stock Issued During Period, Value, New Issues         3,000,000      
Gain (Loss) on Extinguishment of Debt, Total         $ (5,291,616) $ (4,201,668)    
Common Stock [Member]                
Stock Issued During Period, Shares, Employee Benefit Plan         94,684 105,308    
Reclassification of Funds Invested              
Stock Issued During Period, Shares, New Issues         18,320,610      
Stock Issued During Period, Value, New Issues         $ 18,321      
Former Chief Executive Officer and President [Member] | Common Stock [Member]                
Stock Issued During Period, Shares, New Issues 18,500,000 18,500,000            
Platinum Loan Agreement [Member] | Former Chief Executive Officer and President [Member]                
Repayments of Convertible Debt   $ 2,200,000            
Gain (Loss) on Extinguishment of Debt, Total   $ (1,000,000)            
Platinum Loan Agreement [Member] | Former Chief Executive Officer and President [Member] | Common Stock [Member]                
Debt Conversion, Converted Instrument, Shares Issued   16,400,000            
Stock Issued During Period, Value, New Issues   $ 3,200,000            
IPFS [Member] | Notes Payable Issued for Prepayment of Insurance Premiums [Member]                
Debt Instrument, Face Amount   $ 393,000         $ 396,000  
Debt Instrument, Interest Rate, Stated Percentage   5.10%         4.00%  
Series NN Warrants [Member] | UCSD [Member]                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights     1,000,000     1,000,000   1,000,000
Class of Warrant or Right, Grants in Period, Estimated Fair Value     $ 334,000     $ 334,000