Annual report pursuant to Section 13 and 15(d)

Note 17 - Income Taxes - Reconciliations Between the Statutory Federal Income Tax Rate and the Effective Tax Rate (Details)

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Note 17 - Income Taxes - Reconciliations Between the Statutory Federal Income Tax Rate and the Effective Tax Rate (Details) - USD ($)
12 Months Ended
Dec. 22, 2017
Dec. 31, 2018
Dec. 31, 2017
Benefit at statutory rate, amount   $ (3,383,491) $ (6,048,423)
Benefit at statutory rate, percent (35.00%) (21.00%) (34.00%)
Adjustments to valuation allowance, amount   $ 2,458,580 $ (26,080,051)
Adjustments to valuation allowance, percent   15.30% (146.60%)
Adjustments to R&D credit carryforwards, amount   $ 975,840 $ (291,745)
Adjustments to R&D credit carryforwards, percent   6.10% (1.60%)
Tax law changes, amount   $ 28,731,045
Tax law changes, percent   161.50%
Permanent items and other, amount   $ (60,682) $ (373,315)
Permanent items and other, percent   (0.30%) (2.20%)
Benefit per financial statements   $ (9,753) $ (4,062,489)