Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
| | | | | | | | | | | Deferred tax assets: | | | | | | | | | Net operating loss carryforwards | | $ | 66,150,646 | | | $ | 60,129,827 | | R&D credit carryforwards | | | 9,729,673 | | | | 9,465,900 | | Stock compensation | | | 1,368,458 | | | | 1,898,394 | | Intangibles | | | 1,720,761 | | | | 1,921,934 | | Temporary differences | | | 132,476 | | | | 801,002 | | Deferred tax assets before valuation allowance | | | 79,102,014 | | | | 74,217,057 | | Valuation allowance | | | (79,102,014 | ) | | | (74,217,057 | ) | Net deferred tax assets | | $ | — | | | $ | — | |
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Summary of Tax Credit Carryforwards [Table Text Block] |
| | | | | | | | | | | | | | | 1998 | |
2018 | | $ | 17,142,781 | | | $ | 1,173,387 | | 1999 | |
2019 | | | — | | | | 130,359 | | 2000 | |
2020 | | | — | | | | 71,713 | | 2001 | |
2021 | | | — | | | | 39,128 | | 2002 | |
2022 | | | 1,282,447 | | | | 5,350 | | 2003 | |
2023 | | | 337,714 | | | | 2,905 | | 2004 | |
2024 | | | 1,237,146 | | | | 22,861 | | 2005 | |
2025 | | | 2,999,083 | | | | 218,332 | | 2006 | |
2026 | | | 3,049,735 | | | | 365,541 | | 2007 | |
2027 | | | 2,842,078 | | | | 342,898 | | 2008 | |
2028 | | | 2,777,503 | | | | 531,539 | | 2009 | |
2029 | | | 13,727,950 | | | | 596,843 | | 2010 | |
2030 | | | 5,397,680 | | | | 1,094,449 | | 2011 | |
2031 | | | 1,875,665 | | | | 1,950,744 | | 2012 | |
2032 | | | 28,406,659 | | | | 468,008 | | 2013 | |
2033 | | | 37,450,522 | | | | 681,772 | | 2014 | |
2034 | | | 34,088,874 | | | | 816,116 | | 2015 | |
2035 | | | 25,073,846 | | | | 492,732 | | 2016 | |
2036 | | | 15,581,209 | | | | 358,404 | |
Total carryforwards | | $ | 193,270,891 | | | $ | 9,363,081 | |
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Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Benefit at statutory rate | | $ | (2,508,264 | ) | | | (34.0 | )% | | $ | (7,835,163 | ) | | | (34.0 | )% | | $ | (10,322,016 | ) | | | (34.0 | )% | Adjustments to valuation allowance | | | 2,354,656 | | | | 31.9 | % | | | 8,212,163 | | | | 35.7 | % | | | 11,046,650 | | | | 36.4 | % | Adjustments to R&D credit carryforwards | | | (239,049 | ) | | | (3.2 | )% | | | (612,087 | ) | | | (2.7 | )% | | | (340,886 | ) | | | (1.1 | )% | Disqualified debt interest | | | 188,060 | | | | 2.5 | % | | | 438,007 | | | | 1.9 | % | | | — | | | | 0.0 | % | Permanent items and other | | | 204,597 | | | | 2.8 | % | | | (202,920 | ) | | | (0.9 | )% | | | (383,748 | ) | | | (1.3 | )% | Benefit per financial statements | | $ | — | | | | | | | $ | — | | | | | | | $ | — | | | | | |
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