Note 19 - Segments - Segment Information (Details) - USD ($)
|
3 Months Ended |
12 Months Ended |
Dec. 31, 2016 |
Sep. 30, 2016 |
Jun. 30, 2016 |
Mar. 31, 2016 |
Dec. 31, 2015 |
Sep. 30, 2015 |
Jun. 30, 2015 |
Mar. 31, 2015 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
Tc99m tilmanocept sales revenue |
|
$ 9,000
|
$ 18,000
|
$ 4,000
|
$ 9,000
|
$ 6,000
|
$ 9,000
|
|
$ 4,000
|
$ 39,601
|
|
$ 19,075
|
|
$ 13,200
|
Tc99m tilmanocept license revenue |
|
|
1,296,000
|
246,000
|
254,000
|
250,000
|
550,000
|
250,000
|
83,000
|
1,795,625
|
|
1,133,333
|
|
300,000
|
Grant and other revenue |
|
1,022,000
|
511,000
|
917,000
|
686,000
|
540,000
|
477,000
|
654,000
|
190,000
|
3,136,408
|
|
1,860,953
|
|
1,740,896
|
Revenues |
|
|
|
|
|
|
|
|
|
4,971,634
|
|
3,013,361
|
|
2,054,096
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
62,260
|
|
3,226
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
7,138,080
|
|
10,562,729
|
|
15,116,978
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
7,466,487
|
|
10,365,950
|
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
453,549
|
|
522,196
|
|
|
Income (loss) from operations |
|
(3,240,000)
|
(910,000)
|
(2,241,000)
|
(3,758,000)
|
(3,463,000)
|
(4,912,000)
|
(3,443,000)
|
(6,623,000)
|
(10,148,742)
|
[3] |
(18,440,740)
|
[3] |
(22,591,492)
|
Other income (expense), excluding equity in the loss of R-NAV, LLC |
[4] |
|
|
|
|
|
|
|
|
2,786,007
|
|
(4,298,604)
|
|
|
Equity in loss of R-NAV, LLC |
|
|
|
|
|
|
|
|
|
(15,159)
|
|
(305,253)
|
|
(523,809)
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(7,377,894)
|
|
(23,044,597)
|
|
|
Loss from discontinued operations, net of tax effect |
|
(1,764,000)
|
1,702,000
|
(5,865,000)
|
(1,004,000)
|
(564,000)
|
(1,562,000)
|
(1,520,000)
|
(1,309,000)
|
(6,931,137)
|
|
(4,518,938)
|
[5] |
(5,367,801)
|
Net loss |
|
|
|
|
|
|
|
|
|
(14,309,031)
|
|
(27,563,535)
|
|
(35,726,669)
|
Total assets, net of depreciation and amortization |
|
12,461,676
|
|
|
|
14,964,513
|
|
|
|
12,461,676
|
|
14,964,513
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
1,847
|
|
39,001
|
|
1,114,448
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(7,377,894)
|
|
(23,044,597)
|
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
(1,764,000)
|
$ 1,702,000
|
$ (5,865,000)
|
$ (1,004,000)
|
(564,000)
|
$ (1,562,000)
|
$ (1,520,000)
|
$ (1,309,000)
|
(6,931,137)
|
|
(4,518,938)
|
[5] |
$ (5,367,801)
|
UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
12,329,143
|
|
|
|
14,552,834
|
|
|
|
12,329,143
|
|
14,552,834
|
|
|
Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
39,601
|
|
19,075
|
|
|
Total assets, net of depreciation and amortization |
|
132,533
|
|
|
|
411,679
|
|
|
|
132,533
|
|
411,679
|
|
|
Diagnostics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
1,795,625
|
|
1,133,333
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
3,011,642
|
|
1,860,953
|
|
|
Revenues |
|
|
|
|
|
|
|
|
|
4,846,868
|
|
3,013,361
|
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
62,260
|
|
3,226
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
6,375,929
|
|
9,831,834
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
56,317
|
|
232,091
|
|
|
Income (loss) from operations |
[3] |
|
|
|
|
|
|
|
|
(1,647,638)
|
|
(7,053,790)
|
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Equity in loss of R-NAV, LLC |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(1,647,638)
|
|
(7,053,790)
|
|
|
Loss from discontinued operations, net of tax effect |
|
|
|
|
|
|
|
|
|
(6,931,137)
|
|
(5,713,598)
|
[5] |
|
Net loss |
|
|
|
|
|
|
|
|
|
(8,578,775)
|
|
(12,767,388)
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
|
26,589
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(1,647,638)
|
|
(7,053,790)
|
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
(6,931,137)
|
|
(5,713,598)
|
[5] |
|
Diagnostics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
3,815,271
|
|
|
|
4,161,029
|
|
|
|
3,815,271
|
|
4,161,029
|
|
|
Diagnostics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
39,601
|
|
19,075
|
|
|
Total assets, net of depreciation and amortization |
|
131,752
|
|
|
|
410,666
|
|
|
|
131,752
|
|
410,666
|
|
|
Therapeutics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
124,766
|
|
|
|
|
Revenues |
|
|
|
|
|
|
|
|
|
124,766
|
|
|
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
762,151
|
|
730,895
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
63,158
|
|
123,884
|
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Income (loss) from operations |
[3] |
|
|
|
|
|
|
|
|
(700,543)
|
|
(854,779)
|
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
Equity in loss of R-NAV, LLC |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(700,543)
|
|
(854,779)
|
|
|
Loss from discontinued operations, net of tax effect |
|
|
|
|
|
|
|
|
|
|
|
|
[5] |
|
Net loss |
|
|
|
|
|
|
|
|
|
(700,543)
|
|
(854,779)
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(700,543)
|
|
(854,779)
|
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
|
[5] |
|
Therapeutics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
15,075
|
|
|
|
|
|
|
|
15,075
|
|
|
|
|
Therapeutics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenues |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization |
[1] |
|
|
|
|
|
|
|
|
7,403,329
|
|
10,242,066
|
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
397,232
|
|
290,105
|
|
|
Income (loss) from operations |
[3] |
|
|
|
|
|
|
|
|
(7,800,561)
|
|
(10,532,171)
|
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC |
[4] |
|
|
|
|
|
|
|
|
2,786,007
|
|
(4,298,604)
|
|
|
Equity in loss of R-NAV, LLC |
|
|
|
|
|
|
|
|
|
(15,159)
|
|
(305,253)
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(5,029,713)
|
|
(15,136,028)
|
|
|
Loss from discontinued operations, net of tax effect |
|
|
|
|
|
|
|
|
|
|
|
1,194,660
|
[5] |
|
Net loss |
|
|
|
|
|
|
|
|
|
(5,029,713)
|
|
(13,941,368)
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
1,847
|
|
12,412
|
|
|
Net loss from continuing operations |
|
|
|
|
|
|
|
|
|
(5,029,713)
|
|
(15,136,028)
|
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
1,194,660
|
[5] |
|
Corporate Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
8,498,797
|
|
|
|
10,391,805
|
|
|
|
8,498,797
|
|
10,391,805
|
|
|
Corporate Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
$ 781
|
|
|
|
$ 1,013
|
|
|
|
$ 781
|
|
$ 1,013
|
|
|
|
|