Quarterly report pursuant to Section 13 or 15(d)

Note 1 - Summary of Significant Accounting Policies (Details Textual)

Note 1 - Summary of Significant Accounting Policies (Details Textual) - USD ($) $ / shares in Units, shares in Millions	1 Months Ended	3 Months Ended		12 Months Ended
	Mar. 31, 2017	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017	Jan. 01, 2018
Notes Payable, Fair Value Disclosure		$ 2,300,000		$ 2,400,000
Notes Payable, Current, Total		2,276,926		2,353,639
Derivative Liability, Total		63,000		63,000
Deferred Revenue					$ 726,061
Cumulative Effect of New Accounting Principle in Period of Adoption				(700,000)
Platinum Loan Agreement [Member]
Embedded Derivative, Fair Value of Embedded Derivative Liability		0		0
PPCO [Member] \| Platinum Loan Agreement [Member] \| Fair Value, Inputs, Level 3 [Member]
Embedded Derivative, Fair Value of Embedded Derivative Liability		0
Retained Earnings [Member]
Cumulative Effect of New Accounting Principle in Period of Adoption				(700,000)
Accounting Standards Update 2014-09 [Member] \| Retained Earnings [Member]
Cumulative Effect of New Accounting Principle in Period of Adoption					(700,000)
Accounting Standards Update 2014-09 [Member] \| Sayre Pharmaceuticals [Member]
Deferred Revenue					700,000
Accounting Standards Update 2014-09 [Member] \| Sayre Pharmaceuticals [Member] \| Retained Earnings [Member]
Cumulative Effect of New Accounting Principle in Period of Adoption					$ (100,000)
Accounting Standards Update 2016-18 [Member] \| Fiscal Year 2016 [Member]
Prior Period Reclassification Adjustment		5,000,000
Series NN Warrants [Member]
Class of Warrant or Right, Term	5 years
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 1.50		$ 1.50
Series NN Warrants [Member] \| Cardinal Health 414 [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights	10		10
Class of Warrant or Right, Grants in Period, Estimated Fair Value			$ 3,300,000	3,300,000
Series NN Warrants [Member] \| UCSD [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights	1		1
Class of Warrant or Right, Grants in Period, Estimated Fair Value			$ 334,000	334,000
Former Executive [Member]
Accounts Payable, Disputed		$ 96,000		$ 96,000