Quarterly report pursuant to Section 13 or 15(d)

Note 16 - Supplemental Disclosure for Statements of Cash Flows (Details Textual)

v3.8.0.1
Note 16 - Supplemental Disclosure for Statements of Cash Flows (Details Textual) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Interest Paid, Excluding Capitalized Interest, Operating Activities   $ 7,300,000  
Stock Issued During Period, Shares, Employee Benefit Plan 94,684    
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution $ 35,980  
Series NN Warrants [Member] | UCSD [Member]      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   1,000,000  
Class of Warrant or Right, Grants in Period, Estimated Fair Value   $ 334,000 $ 334,000