Quarterly report pursuant to Section 13 or 15(d)

Note 9 - Notes Payable (Details Textual)

Note 9 - Notes Payable (Details Textual) - USD ($)								1 Months Ended				3 Months Ended
Note 9 - Notes Payable (Details Textual) - USD ($)	Apr. 12, 2018	Apr. 09, 2018	Mar. 26, 2018	Jan. 16, 2018	Nov. 02, 2017	Mar. 31, 2017	Mar. 03, 2017	Dec. 31, 2017	Nov. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Mar. 31, 2018	Mar. 31, 2017	Jul. 31, 2012
Notes Payable, Current, Total								$ 2,353,639				$ 2,276,926
Interest Expense, Debt, Total												44,000	$ 1,700,000
Interest Expense Recorded Related to Amortization of Debt Discounts and Deferred Financing Costs												42,000	143,000
Subsequent Event [Member] \| CRG [Member]
Draws on Letter of Credit		$ 7,100,000
Platinum-Montaur Life Sciences LLC Litigation [Member] \| Pending Litigation [Member]
Loss Contingency, Damages Sought, Value					$ 1,900,000
CRG Loan Agreement, Texas Case [Member] \| Pending Litigation [Member]
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration				$ 4,100,000
Loss Contingency, Damages Awarded,Value, Requested Modified Amount				2,900,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount							$ 7,000,000	7,000,000
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration				4,100,000				4,100,000
Loss Contingency, Damages Awarded,Value, Requested Modified Amount				$ 2,900,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member] \| Surety Bond [Member]
Loss Contingency, Amount Awarded to Other Party			$ 7,700,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member] \| Maximum [Member]
Loss Contingency, Damages Awarded, Value							66,000,000	66,000,000
CRG Loan Agreement, Ohio Case [Member] \| Pending Litigation [Member] \| Subsequent Event [Member]
Loss Contingency, Damages Sought, Value	$ 4,100,000
Platinum Loan Agreement [Member]
Interest Expense, Debt, Excluding Amortization												42,000	143,000
Convertible Debt, Fair Value Disclosures								2,000,000				2,100,000
Embedded Derivative, Fair Value of Embedded Derivative Liability								0				0
Notes Payable Issued for Prepayment of Insurance Premiums [Member]
Notes Payable, Current, Total								$ 318,000				200,000
Notes Payable Issued for Prepayment of Insurance Premiums [Member] \| IPFS [Member]
Debt Instrument, Face Amount									$ 396,000		$ 348,000
Debt Instrument, Interest Rate, Stated Percentage									4.00%		8.99%
Debt Instrument, Term									300 days		240 days
Debt Instrument, Periodic Payment, Total									$ 40,000		$ 45,000
PPCO [Member] \| Platinum Loan Agreement [Member]
Line of Credit Facility, Maximum Borrowing Capacity														$ 50,000,000
Repayments of Debt							7,700,000
Convertible Debt, Total							1,900,000
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total												$ 0	$ (140,000)
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Repayments of Debt						$ 59,000,000	$ 59,000,000			$ 59,000,000