Quarterly report pursuant to Section 13 or 15(d)

Note 9 - Notes Payable (Details Textual)

v3.8.0.1
Note 9 - Notes Payable (Details Textual) - USD ($)
1 Months Ended 3 Months Ended
Apr. 12, 2018
Apr. 09, 2018
Mar. 26, 2018
Jan. 16, 2018
Nov. 02, 2017
Mar. 31, 2017
Mar. 03, 2017
Dec. 31, 2017
Nov. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Mar. 31, 2018
Mar. 31, 2017
Jul. 31, 2012
Notes Payable, Current, Total               $ 2,353,639       $ 2,276,926    
Interest Expense, Debt, Total                       44,000 $ 1,700,000  
Interest Expense Recorded Related to Amortization of Debt Discounts and Deferred Financing Costs                       42,000 143,000  
Subsequent Event [Member] | CRG [Member]                            
Draws on Letter of Credit   $ 7,100,000                        
Platinum-Montaur Life Sciences LLC Litigation [Member] | Pending Litigation [Member]                            
Loss Contingency, Damages Sought, Value         $ 1,900,000                  
CRG Loan Agreement, Texas Case [Member] | Pending Litigation [Member]                            
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration       $ 4,100,000                    
Loss Contingency, Damages Awarded,Value, Requested Modified Amount       2,900,000                    
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                            
Loss Contingency, Damages Awarded, Value, Additional Amount             $ 7,000,000 7,000,000            
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration       4,100,000       4,100,000            
Loss Contingency, Damages Awarded,Value, Requested Modified Amount       $ 2,900,000                    
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member] | Surety Bond [Member]                            
Loss Contingency, Amount Awarded to Other Party     $ 7,700,000                      
CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member] | Maximum [Member]                            
Loss Contingency, Damages Awarded, Value             66,000,000 66,000,000            
CRG Loan Agreement, Ohio Case [Member] | Pending Litigation [Member] | Subsequent Event [Member]                            
Loss Contingency, Damages Sought, Value $ 4,100,000                          
Platinum Loan Agreement [Member]                            
Interest Expense, Debt, Excluding Amortization                       42,000 143,000  
Convertible Debt, Fair Value Disclosures               2,000,000       2,100,000    
Embedded Derivative, Fair Value of Embedded Derivative Liability               0       0    
Notes Payable Issued for Prepayment of Insurance Premiums [Member]                            
Notes Payable, Current, Total               $ 318,000       200,000    
Notes Payable Issued for Prepayment of Insurance Premiums [Member] | IPFS [Member]                            
Debt Instrument, Face Amount                 $ 396,000   $ 348,000      
Debt Instrument, Interest Rate, Stated Percentage                 4.00%   8.99%      
Debt Instrument, Term                 300 days   240 days      
Debt Instrument, Periodic Payment, Total                 $ 40,000   $ 45,000      
PPCO [Member] | Platinum Loan Agreement [Member]                            
Line of Credit Facility, Maximum Borrowing Capacity                           $ 50,000,000
Repayments of Debt             7,700,000              
Convertible Debt, Total             1,900,000              
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total                       $ 0 $ (140,000)  
CRG [Member] | Term Loan Agreement [Member] | CRG Loan Agreement, Texas Case [Member] | Judicial Ruling [Member]                            
Repayments of Debt           $ 59,000,000 $ 59,000,000     $ 59,000,000