Quarterly report pursuant to Section 13 or 15(d)

Note 14 - Income Taxes (Details Textual)

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Note 14 - Income Taxes (Details Textual) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 21.00%   35.00%
Unrecognized Tax Benefits, Ending Balance $ 0   $ 0
Open Tax Year 2014 2015 2016 2017    
Income Tax Expense (Benefit), Total $ 0 $ (1,454,172)  
Effective Income Tax Rate Reconciliation, Percent, Total 0.00% 33.70%  
Domestic Tax Authority [Member] | Internal Revenue Service (IRS) [Member]      
Operating Loss Carryforwards, Total $ 131,800,000    
Domestic Tax Authority [Member] | Internal Revenue Service (IRS) [Member] | Research Tax Credit Carryforward [Member]      
Tax Credit Carryforward, Amount 9,700,000    
State and Local Jurisdiction [Member]      
Operating Loss Carryforwards, Total 20,400,000    
Other Noncurrent Assets [Member]      
Deferred Tax Assets, Tax Credit Carryforwards, Alternative Minimum Tax $ 1,200,000   $ 1,200,000