Annual report pursuant to Section 13 and 15(d)

Note 2 - Liquidity (Details Textual)

v3.21.1
Note 2 - Liquidity (Details Textual)
 1 Months Ended 2 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended
Mar. 16, 2021
USD ($)
Mar. 02, 2021
USD ($)
shares
Feb. 23, 2021
USD ($)
Aug. 31, 2020
USD ($)
shares
Aug. 30, 2020
USD ($)
$ / shares
shares
Aug. 09, 2020
USD ($)
shares
May 18, 2020
USD ($)
May 06, 2020
USD ($)
shares
Nov. 27, 2019
USD ($)
Mar. 22, 2019
USD ($)
$ / shares
Feb. 29, 2020
USD ($)
shares
Jan. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
$ / shares
Jun. 30, 2019
USD ($)
$ / shares
shares
Nov. 30, 2017
USD ($)
Jan. 31, 2020
USD ($)
shares
Mar. 25, 2021
USD ($)
shares
Mar. 31, 2020
USD ($)
Dec. 31, 2020
USD ($)
$ / shares
Sep. 30, 2020
USD ($)
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
Apr. 26, 2019
$ / shares
Stock Issued During Period, Shares, New Issues (in shares) | shares                               2,100,000              
Proceeds from Issuance of Common Stock                       $ 812,000 $ 1,100,000     $ 1,900,000         $ 4,442,560 $ 7,086,915  
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                                   $ 4,975,000   4,975,000  
Stock Issued During Period, Value, New Issues                                         1,250,000 5,166,441  
Proceeds from Issuance of Preferred Stock and Preference Stock                                         $ 5,975,000  
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares                         $ 0.001           $ 0.001   $ 0.001 $ 0.001 $ 0.001
Proceeds from Notes Payable, Total                                         $ 366,000  
Paycheck Protection Program CARES Act [Member]                                              
Proceeds from Notes Payable, Total             $ 366,000                                
Series C Preferred Stock [Member]                                              
Stock Issued During Period, Value, New Issues                                         4,163,178    
Series D Preferred Stock [Member]                                              
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                                     $ 2,900,000   2,900,000    
Stock Issued During Period, Value, New Issues                                         $ 132,107    
Investor [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                     4,000,000                   4,020,588    
Proceeds from Issuance of Common Stock                     $ 3,400,000                 $ 3,400,000      
Accounts and Other Receivables [Member]                                              
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                         $ 812,000                 812,000  
Keystone Capital Partners, LLC [Member] | Series C Preferred Stock [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares               420,000     420,000                   420,000    
Proceeds from Issuance of Common Stock                                         $ 4.20    
Stock Issued During Period, Value, New Issues               $ 4,200,000     $ 4,200,000                        
Proceeds from Issuance of Preferred Stock and Preference Stock                                     4,200,000        
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares       150,000                                 17,750    
Stock Issued During Period, Value, New Issues       $ 15,000,000                                      
Proceeds from Issuance of Preferred Stock and Preference Stock                                         $ 1,800,000    
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member] | Maximum [Member]                                              
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares       5,147,000                                      
Jubilant [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares           209,205                                  
Proceeds from Issuance of Common Stock           $ 1,000,000                                  
Underwritten Public Offering [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                           8,000,000                  
Shares Issued, Price Per Share (in dollars per share) | $ / shares                           $ 0.75                  
Proceeds from Issuance of Common Stock                           $ 5,555,000                  
Underwritten Public Offering [Member] | John K. Scott, Jr. [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                           4,000,000                  
Shares Issued, Price Per Share (in dollars per share) | $ / shares                           $ 0.75                  
Underwritten Public Offering [Member] | Underwriter [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                           4,000,000                  
Shares Issued, Price Per Share (in dollars per share) | $ / shares                           $ 0.69375                  
Private Placement [Member]                                              
Shares Issued, Price Per Share (in dollars per share) | $ / shares                   $ 2.80                          
Stock Issued During Period, Value, New Issues                   $ 50,000                     $ 2,059 $ 1,090,000  
Private Placement [Member] | Investor [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                                         5,000    
Sale of Stock, Commitment Amount         $ 25,000                                    
Private Placement [Member] | Jubilant [Member]                                              
Sale of Stock, Commitment Amount           1,000,000                                  
Sale of Stock, Additional Milestone Commitment Amount           $ 19,000,000                                  
Private Placement [Member] | Mastiff Group LLC [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares         1,000,000                                    
Shares Issued, Price Per Share (in dollars per share) | $ / shares         $ 5                                    
Sale of Stock, Commitment Amount         $ 25,000,000                           $ 4,975,000   $ 4,975,000    
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares         $ 0.001                                    
Private Placement [Member] | Mastiff Group LLC [Member] | Maximum [Member]                                              
Shares Issued, Price Per Share (in dollars per share) | $ / shares         $ 5.75                                    
Subsequent Event [Member] | Paycheck Protection Program CARES Act [Member]                                              
Forgiveness of Notes Payable     $ 366,000                                        
Subsequent Event [Member] | John K. Scott, Jr. [Member] | Series E Preferred Stock [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares   50,000                                          
Stock Issued During Period, Value, New Issues   $ 5,000,000                                          
Debt Instrument, Convertible, Number of Equity Instruments   2,173,913                                          
Subsequent Event [Member] | Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member]                                              
Stock Issued During Period, Shares, New Issues (in shares) | shares                                 29,250            
Proceeds from Issuance of Common Stock                                 $ 4,700,000            
Proceeds from Issuance of Preferred Stock and Preference Stock                                 2,900,000            
Subsequent Event [Member] | Private Placement [Member] | Mastiff Group LLC [Member]                                              
Proceeds from Issuance of Common Stock                                 $ 25,000            
Platinum-Montaur Life Sciences LLC Litigation [Member]                                              
Loss Contingency, Damages Sought, Value                             $ 1,900,000                
CRG Loan Agreement, Ohio Case [Member]                                              
Loss Contingency, Damages Sought, Value                                   $ 4,300,000          
Ohio Court of Common Pleas [Member]                                              
Litigation Settlement, Amount Awarded from Other Party                 $ 4,300,000                            
Ohio Court of Common Pleas [Member] | Subsequent Event [Member]                                              
Litigation Settlement, Reversal of Amount Awarded from Other Party $ 4,300,000