Annual report pursuant to Section 13 and 15(d)

Note 14 - Equity Instruments (Details Textual)

v3.21.1
Note 14 - Equity Instruments (Details Textual) - USD ($)
 1 Months Ended 2 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended
Aug. 31, 2020
Aug. 30, 2020
Aug. 09, 2020
May 06, 2020
Mar. 22, 2019
May 31, 2020
Feb. 29, 2020
Jan. 31, 2020
Dec. 31, 2019
Jun. 30, 2019
Nov. 30, 2018
Jan. 31, 2020
Mar. 25, 2021
Dec. 31, 2020
Sep. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Mar. 31, 2020
Mar. 31, 2019
Mar. 11, 2015
Stock Issued During Period, Value, New Issues                               $ 1,250,000 $ 5,166,441      
Stock Issued During Period, Shares, New Issues (in shares)                       2,100,000                
Proceeds from Issuance of Common Stock               $ 812,000 $ 1,100,000     $ 1,900,000       4,442,560 7,086,915      
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                         $ 4,975,000   4,975,000      
Proceeds from Issuance of Preferred Stock and Preference Stock                               5,975,000      
Preferred Stock, Shares Subscribed but Unissued, Subscriptions Receivable                         $ 10,300,000   10,300,000      
Stock Issued During Period, Value, Issued for Services                               $ 70,201 $ 14,800      
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares)                               32,651 8,128      
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution                               $ 39,834 $ 19,588      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                           992,000   992,000        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) [1]                           $ 18.37   $ 18.37        
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                           1,541,844   1,541,844        
Series OO Warrants [Member]                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                           $ 0.9375   $ 0.9375        
Class of Warrant or Right, Exercised During Period (in shares)           411,000                   411,000        
Issued Stock Upon Exercise of Warrants, Shares (in shares)           300,595                   300,595        
Common Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 1,647 $ 8,000      
Stock Issued During Period, Shares, New Issues (in shares)                               1,647,059 8,000,000      
Stock Issued During Period, Shares, Issued for Services (in shares)                               23,810 20,000      
Stock Issued During Period, Value, Issued for Services                               $ 24 $ 20      
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares)                               94,159        
Issued Stock Upon Exercise of Warrants, Shares (in shares)                               300,595        
Common Stock [Member] | Former Chief Executive Officer and President [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                     925,000                  
Stock Issued During Period, Shares, New Issues Placed in Escrow (in shares)                     250,000         250,000        
Common Stock [Member] | Macrophage Therapeutics [Member]                                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                                   300   300
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                                   $ 2,000    
Conversion from Series C Preferred Stock To Common Stock [Member]                                        
Conversion of Stock, Shares Converted (in shares)                               420,000        
Conversion of Stock, Shares Issued (in shares)                               1,425,076        
Conversion from Series D Preferred Stock To Common Stock [Member]                                        
Conversion of Stock, Shares Converted (in shares)                               17,750        
Conversion of Stock, Shares Issued (in shares)                               827,280        
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                           4,319,720   4,319,720        
Conversion from Series D Preferred Stock To Common Stock [Member] | Subsequent Event [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                         29,250              
Conversion of Stock, Shares Converted (in shares)                         29,250              
Conversion of Stock, Shares Issued (in shares)                         1,375,089              
Series C Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 4,163,178        
Preferred Stock, Deemed Dividend                               $ 467,000        
Conversion of Stock, Shares Converted (in shares)                               420,000        
Series C Preferred Stock [Member] | Common Stock [Member]                                        
Stock Issued During Period, Value, New Issues                                      
Stock Issued During Period, Shares, New Issues (in shares)                                      
Series D Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 132,107        
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                           $ 2,900,000   2,900,000        
Preferred Stock, Deemed Dividend                               $ 197,000        
Conversion of Stock, Shares Converted (in shares)                               17,750        
Stock Subscriptions Receivable                           2,900,000   $ 2,900,000        
Preferred Stock, Shares Subscribed but Unissued, Subscriptions Receivable                           10,300,000   10,300,000        
Series D Preferred Stock [Member] | Common Stock [Member]                                        
Stock Issued During Period, Value, New Issues                                      
Stock Issued During Period, Shares, New Issues (in shares)                                      
Investor [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)             4,000,000                 4,020,588        
Proceeds from Issuance of Common Stock             $ 3,400,000               $ 3,400,000          
Employees [Member] | Common Stock [Member]                                        
Stock Issued During Period, Shares, Issued for Services (in shares)                               94,159 0      
Stock Issued During Period, Value, Issued for Services                               $ 172,000        
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares)                               94,159        
Issuance of Stock to Defined Contribution Plan for Employer Matching Contribution                               $ 172,000        
Prepaid Expenses and Other Current Assets [Member]                                        
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                 $ 812,000               $ 812,000      
Keystone Capital Partners, LLC [Member] | Series C Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues       $ 4,200,000     $ 4,200,000                          
Stock Issued During Period, Shares, New Issues (in shares)       420,000     420,000                 420,000        
Proceeds from Issuance of Common Stock                               $ 4.20        
Convertible Preferred Stock, Discount to Market Rate             10.00%                          
Convertible Preferred Stock, Maximum Allowed Percentage of Common Stock Outstanding Used in Conversion Shares             19.99%                          
Proceeds from Issuance of Preferred Stock and Preference Stock                           $ 4,200,000            
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues $ 15,000,000                                      
Stock Issued During Period, Shares, New Issues (in shares) 150,000                             17,750        
Convertible Preferred Stock, Discount to Market Rate 10.00%                                      
Convertible Preferred Stock, Maximum Allowed Percentage of Common Stock Outstanding Used in Conversion Shares 19.99%                                      
Preferred Stock, Deemed Dividend                               $ 197,000        
Stock Issued During Period, Value, Other $ 15                                      
Proceeds from Issuance of Preferred Stock and Preference Stock                               $ 1,800,000        
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member] | Subsequent Event [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                         29,250              
Proceeds from Issuance of Common Stock                         $ 4,700,000              
Proceeds from Issuance of Preferred Stock and Preference Stock                         2,900,000              
Jubilant [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)     209,205                                  
Proceeds from Issuance of Common Stock     $ 1,000,000                                  
Maximum [Member]                                        
Warrants and Rights Outstanding, Term (Year)                           14 years 219 days   14 years 219 days        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                           $ 49.80   $ 49.80        
Minimum [Member]                                        
Warrants and Rights Outstanding, Term (Year)                           73 days   73 days        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                           $ 0.20   $ 0.20        
Weighted Average [Member]                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                           $ 18.37   $ 18.37        
Private Placement [Member]                                        
Stock Issued During Period, Value, New Issues         $ 50,000                     $ 2,059 1,090,000      
Shares Issued, Price Per Share (in dollars per share)         $ 2.80                              
Private Placement [Member] | Common Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 3,281 $ 1,513      
Stock Issued During Period, Shares, New Issues (in shares)                               3,280,691 1,173,411      
Private Placement [Member] | Investor [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                               5,000        
Sale of Stock, Commitment Amount   $ 25,000                                    
Private Placement [Member] | Jubilant [Member]                                        
Sale of Stock, Commitment Amount     $ 1,000,000                                  
Private Placement [Member] | Mastiff Group LLC [Member]                                        
Shares Issued, Price Per Share (in dollars per share)   $ 5                                    
Stock Issued During Period, Shares, New Issues (in shares)   1,000,000                                    
Sale of Stock, Commitment Amount   $ 25,000,000                       $ 4,975,000   $ 4,975,000        
Private Placement [Member] | Mastiff Group LLC [Member] | Subsequent Event [Member]                                        
Proceeds from Issuance of Common Stock                         $ 25,000              
Private Placement [Member] | Maximum [Member]                                        
Stock Purchase Agreement, Maximum Value                                     $ 3,000,000  
Private Placement [Member] | Maximum [Member] | Mastiff Group LLC [Member]                                        
Shares Issued, Price Per Share (in dollars per share)   $ 5.75                                    
Underwritten Public Offering [Member]                                        
Shares Issued, Price Per Share (in dollars per share)                   $ 0.75                    
Stock Issued During Period, Shares, New Issues (in shares)                   8,000,000                    
Commission to Underwriter, Percentage of Gross Proceeds                   7.50%                    
Stock Issued, Management Fee, Percentage                   1.00%                    
Proceeds from Issuance of Common Stock                   $ 5,555,000                    
Professional Fees                   $ 127,000                    
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                           995,000   995,000        
Underwritten Public Offering [Member] | Underwriter Warrants [Member]                                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                   600,000                    
Common Stock Called By Warrants As Percentage Of Common Stock Sold                   7.50%                    
Warrants and Rights Outstanding, Term (Year)                   5 years                    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                   $ 0.9375                    
Percent of Offering Price to Public Per Share                   125.00%                    
Class of Warrant or Right, Grants in Period, Estimated Fair Value                   $ 261,000                    
Underwritten Public Offering [Member] | Underwriter Warrants [Member] | Measurement Input, Price Volatility [Member]                                        
Warrants and Rights Outstanding, Measurement Input                   0.886                    
Underwritten Public Offering [Member] | Underwriter Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                                        
Warrants and Rights Outstanding, Measurement Input                   0.018                    
Underwritten Public Offering [Member] | Underwriter Warrants [Member] | Measurement Input, Expected Dividend Payment [Member]                                        
Warrants and Rights Outstanding, Measurement Input                   0                    
Underwritten Public Offering [Member] | Non-accountable Expenses [Member]                                        
Payments of Stock Issuance Costs                   $ 50,000                    
Underwritten Public Offering [Member] | Fees and Expenses of Legal Counsel [Member]                                        
Payments of Stock Issuance Costs                   100,000                    
Underwritten Public Offering [Member] | Clearing Expenses [Member]                                        
Payments of Stock Issuance Costs                   $ 10,000                    
Underwritten Public Offering [Member] | Offering Investor [Member]                                        
Shares Issued, Price Per Share (in dollars per share)                   $ 0.75                    
Stock Issued During Period, Shares, New Issues (in shares)                   4,000,000                    
Underwritten Public Offering [Member] | Underwriter [Member]                                        
Shares Issued, Price Per Share (in dollars per share)                   $ 0.69375                    
Stock Issued During Period, Shares, New Issues (in shares)                   4,000,000                    
Over-Allotment Option [Member] | Underwriter [Member]                                        
Shares Issued, Price Per Share (in dollars per share)                   $ 0.69375                    
Stock Issued During Period, Shares, New Issues (in shares)                   1,200,000                    
[1] Weighted average exercise price.