Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details 2)

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Income Taxes (Details 2) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Amount      
Benefit at statutory rate $ (4,864,851) $ (9,777,786) $ (12,147,068)
Adjustments to valuation allowance 4,838,082 9,728,667 12,925,380
Adjustments to R&D credit carryforwards (239,049) (612,087) (340,886)
Disqualified debt interest 188,060 438,007 0
Permanent items and other 77,758 (212,852) (437,426)
Benefit per financial statements $ 0 $ (436,051) $ 0
Percent      
Benefit at statutory rate (34.00%) (34.00%) (34.00%)
Adjustments to valuation allowance 33.80% 33.80% 36.20%
Adjustments to R&D credit carryforwards (1.60%) (2.10%) (1.00%)
Disqualified debt interest 1.30% 1.50% 0.00%
Permanent items and other 0.50% (0.70%) (1.20%)