Annual report pursuant to Section 13 and 15(d)

Cover
- Document And Entity Information
Financial Statements
Notes to Financial Statements
Accounting Policies
- Significant Accounting Policies (Policies)
Notes Tables
Notes Details

Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)

v3.22.1

Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Patent and Trademark Costs	$ 304,000	$ 278,000
Previously Capitalized Patent Costs Abandoned	99,000	9,000
Estimated Litigation Liability	0
Unrecognized Tax Benefits, Ending Balance	$ 0	$ 0
Minimum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	5 years
Maximum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	15 years
The 2014 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares)	1,750,000
The 2014 Plan [Member] \| Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)	1 year
The 2014 Plan [Member] \| Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)	4 years
The 2002 and 2014 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)	10 years
The 2002 and 2014 Plan [Member] \| Grantee Status, Former Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)	90 days
Navidea Biopharmaceuticals Limited [Member]
Noncontrolling Interest, Ownership Percentage by Parent	100.00%
Macrophage Therapeutics [Member]
Noncontrolling Interest, Ownership Percentage by Parent	99.90%
Navidea Europe [Member]
Noncontrolling Interest, Ownership Percentage by Parent	100.00%

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