Annual report pursuant to Section 13 and 15(d)

Note 12 - Commitments and Contingencies (Details Textual)

Note 12 - Commitments and Contingencies (Details Textual) - USD ($)										1 Months Ended			12 Months Ended
	Dec. 09, 2021	Nov. 21, 2021	May 27, 2021	Mar. 16, 2021	Nov. 27, 2019	Aug. 14, 2018	Apr. 09, 2018	Nov. 02, 2017	Mar. 03, 2017	Nov. 30, 2018	Apr. 30, 2018	Jun. 30, 2016	Dec. 31, 2021	Sep. 30, 2021	Dec. 31, 2020	Dec. 31, 2019	Aug. 31, 2018
Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest, Ending Balance													$ 624,743	$ 4,100,000	$ 2,046,907	$ (880,989)
Common Stock [Member]
Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest, Ending Balance													$ 221,277		$ 218,146	$ 210,232
Former Chief Executive Officer and President [Member]
Common Stock Shares Provided by Agreement (in shares)																	1,175,000
Common Stock Shares Provided by Agreement, Escrow Period (Month)						18 months
Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares)										925,000
Stock Issued During Period, Shares, New Issues Placed in Escrow (in shares)										250,000			250,000
Former Chief Executive Officer and President [Member] \| MT [Member] \| Common Stock [Member] \| Dr. Michael Goldberg [Member]
Ownership Percentage						5.00%
CRG [Member]
Draws on Letter of Credit							$ 7,100,000
CRG Loan Agreement, Texas Case [Member]
Litigation Settlement, Attorneys’ Fees		$ 2,800,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount									$ 7,000,000.0
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration												$ 4,100,000
Ohio Court of Common Pleas [Member]
Litigation Settlement, Amount Awarded from Other Party					$ 4,300,000
Litigation Settlement, Reversal of Amount Awarded from Other Party				$ 4,300,000
Platinum-Montaur Life Sciences LLC Litigation [Member] \| Pending Litigation [Member]
Loss Contingency, Damages Sought, Value								$ 1,900,000
New York Litigation Involving Former CEO and President [Member] \| Judicial Ruling [Member]
Litigation Settlement, Amount Can Be Awarded to Other Party for Indemnification for Attorneys’ Fees			$ 14,955
Litigation Settlement, Amount Can Be Advanced to Other Party for Attorneys’ Fees Subject to Repayment			$ 1,237.50
Delaware Litigation Involving Former CEO and President [Member]
Litigation Settlement, Amount Awarded from Other Party	$ 66,796.33
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member]
Overpayment of Debt											$ 4,200,000
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Repayments of Debt									59,000,000.0
CRG [Member] \| Term Loan Agreement [Member] \| Maximum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount									$ 66,000,000.0