Annual report pursuant to Section 13 and 15(d)

Note 13 - Equity Instruments (Details Textual)

v3.22.1
Note 13 - Equity Instruments (Details Textual) - USD ($)
 1 Months Ended 2 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 10 Months Ended 12 Months Ended 16 Months Ended
Jul. 08, 2021
Mar. 02, 2021
Aug. 31, 2020
Aug. 30, 2020
Aug. 09, 2020
May 06, 2020
Feb. 29, 2020
Jan. 31, 2020
Dec. 31, 2019
Nov. 30, 2018
Jan. 31, 2020
Mar. 25, 2021
Sep. 30, 2020
Sep. 30, 2020
Jul. 07, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2021
Jun. 30, 2021
Mar. 31, 2020
Proceeds from Issuance of Common Stock                               $ 4,346 $ 4,442,560      
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                               (0) 4,975,000 $ (0)    
Proceeds from Issuance of Preferred Stock and Preference Stock                               $ 12,682,700 $ 5,975,000      
Stock Issued During Period, Shares, Employee Benefit Plan (in shares)                               30,018 32,651      
Stock Issued During Period, Value, Employee Benefit Plan                               $ 76,846 $ 39,834      
Stock Issued During Period, Value, Issued for Employee Bonuses                                 $ 171,522      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                               972,324   972,324    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) [1]                               $ 17.97   $ 17.97    
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                               1,892,114   1,892,114    
Director [Member]                                        
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                               49,242   49,242    
Common Stock [Member]                                        
Stock Issued During Period, Shares, Employee Benefit Plan (in shares)                               30,018 32,651      
Stock Issued During Period, Value, Employee Benefit Plan                               $ 30 $ 33      
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares)                                 94,159      
Stock Issued During Period, Value, Issued for Employee Bonuses                                 $ 94      
Common Stock [Member] | Former Chief Executive Officer and President [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                   925,000                    
Stock Issued During Period, Shares, New Issues Placed in Escrow (in shares)                   250,000           250,000        
Common Stock [Member] | Macrophage Therapeutics [Member]                                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                                       300
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                                       $ 2,000
Maximum [Member]                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                               $ 49.80   $ 49.80    
Warrants and Rights Outstanding, Term (Year)                               13 years 7 months 6 days   13 years 7 months 6 days    
Minimum [Member]                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                               $ 0.20   $ 0.20    
Warrants and Rights Outstanding, Term (Year)                               2 months 12 days   2 months 12 days    
Weighted Average [Member]                                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                               $ 17.97   $ 17.97    
Conversion from Series C Preferred Stock To Common Stock [Member]                                        
Conversion of Stock, Shares Converted (in shares)                                 420,000      
Conversion of Stock, Shares Issued (in shares)                                 1,425,076      
Conversion from Series D Preferred Stock To Common Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                             72,500          
Conversion of Stock, Shares Converted (in shares)                       29,250       54,750 17,750      
Conversion of Stock, Shares Issued (in shares)                       1,375,089       2,951,509 827,280 3,778,789    
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                               1,368,211   1,368,211    
Conversion from Series E Preferred Stock To Common Stock [Member                                        
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                               2,173,913   2,173,913    
Series C Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues                                 $ 4,163,178      
Preferred Stock, Deemed Dividend                                 $ 467,000      
Conversion of Stock, Shares Converted (in shares)                           420,000     420,000      
Series C Preferred Stock [Member] | Common Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                                 0      
Stock Issued During Period, Value, New Issues                                 $ 0      
Series D Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 2,550,001 132,107      
Preferred Stock, Deemed Dividend                                 $ 197,000      
Conversion of Stock, Shares Converted (in shares)                                 17,750      
Preferred Stock, Shares Subscribed but Unissued, Subscriptions Receivable                               $ (0) $ 10,300,000 $ (0)    
Preferred Stock, Shares Outstanding, Ending Balance (in shares)                               22,077 0 22,077    
Series D Preferred Stock [Member] | Common Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                                 0      
Stock Issued During Period, Value, New Issues                                 $ 0      
Series D Preferred Stock [Member] | Stock Subscriptions and Other Receivables [Member]                                        
Stock Subscriptions Receivable                                 $ 2,900,000      
Series E Preferred Stock [Member]                                        
Stock Issued During Period, Value, New Issues                               $ 4,930,038        
Preferred Stock, Shares Outstanding, Ending Balance (in shares)                               50,000 0 50,000    
Preferred Stock, Convertible, Conversion Price (in dollars per share)   $ 2.30                                    
Preferred Stock, Redemption Price Per Share (in dollars per share)   $ 110                                    
Keystone Capital Partners, LLC [Member] | Series C Preferred Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)           420,000                     420,000      
Proceeds from Issuance of Common Stock                                 $ 4.2      
Stock Issued During Period, Value, New Issues           $ 4,200,000                            
Convertible Preferred Stock, Discount to Market Rate           10.00%                            
Convertible Preferred Stock, Maximum Allowed Percentage of Common Stock Outstanding Used in Conversion Shares           19.99%                            
Proceeds from Issuance of Preferred Stock and Preference Stock                         $ 4,200,000              
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares) 22,077   150,000                 29,250     72,500 76,827 17,750      
Stock Issued During Period, Value, New Issues $ 2,200,000   $ 15,000,000.0                       $ 7,250,000 $ 7,700,000        
Convertible Preferred Stock, Discount to Market Rate     10.00%                                  
Convertible Preferred Stock, Maximum Allowed Percentage of Common Stock Outstanding Used in Conversion Shares     19.99%                                  
Preferred Stock, Deemed Dividend                                 $ 197,000      
Stock Issued During Period, Value, Other     $ 15.0                                  
Convertible Preferred Stock, Shares Issued upon Conversion (in shares)     5,147,000                                  
Proceeds from Issuance of Preferred Stock and Preference Stock                       $ 2,900,000         $ 1,800,000      
Preferred Stock, Shares Outstanding, Ending Balance (in shares)                               22,077   22,077    
Keystone Capital Partners, LLC [Member] | Series D Preferred Stock [Member] | Maximum [Member]                                        
Convertible Preferred Stock, Shares Issued upon Conversion (in shares)     5,147,000                                  
Jubilant [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)         209,205                              
Proceeds from Issuance of Common Stock         $ 1,000,000.0                              
John K. Scott, Jr. [Member] | Series E Preferred Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)   50,000                                    
Stock Issued During Period, Value, New Issues   $ 5,000,000.0                                    
Percentage of Securities Allowed to be Purchased in Third-Party Offering, Maximum   33.33%                                    
Investor [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)             4,000,000.0                   4,020,588      
Proceeds from Issuance of Common Stock             $ 3,400,000             $ 3,400,000            
Employees [Member] | Common Stock [Member]                                        
Stock Issued During Period, Shares, Issued for Employee Bonuses (in shares)                                 94,159      
Stock Issued During Period, Value, Issued for Employee Bonuses                               $ 0 $ 172,000      
Private Placement [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                     2,100,000                  
Proceeds from Issuance of Common Stock               $ 812,000 $ 1,100,000   $ 1,900,000                  
Stock Issued During Period, Value, New Issues                                 $ 2,059      
Private Placement [Member] | Common Stock [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                                 3,280,691      
Stock Issued During Period, Value, New Issues                                 $ 3,281      
Private Placement [Member] | Jubilant [Member]                                        
Sale of Stock, Commitment Amount         $ 1,000,000.0                              
Private Placement [Member] | Mastiff Group LLC [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)       1,000,000                                
Proceeds from Issuance of Common Stock                       $ 25,000                
Sale of Stock, Commitment Amount       $ 25,000,000.0                                
Shares Issued, Price Per Share (in dollars per share)       $ 5.00                                
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                                     $ 4,975,000  
Private Placement [Member] | Mastiff Group LLC [Member] | Stock Subscriptions and Other Receivables [Member]                                        
Common Stock, Share Subscribed but Unissued, Subscriptions Receivable                                 $ 4,975,000   $ 4,975,000  
Private Placement [Member] | Mastiff Group LLC [Member] | Maximum [Member]                                        
Shares Issued, Price Per Share (in dollars per share)       $ 5.75                                
Private Placement [Member] | John K. Scott, Jr. [Member]                                        
Stock Issued During Period, Shares, New Issues (in shares)                                 5,000      
Sale of Stock, Commitment Amount       $ 25,000                                
[1] Weighted average exercise price.