Annual report pursuant to Section 13 and 15(d)

Note 2 - Liquidity (Details Textual)

v3.23.1
Note 2 - Liquidity (Details Textual) - USD ($)
Aug. 30, 2022
Aug. 11, 2022
Aug. 03, 2022
Jul. 01, 2022
Apr. 10, 2022
Dec. 31, 2022
Oct. 11, 2022
Rights Offering, Shares Authorized 35,000   35,000        
Shares Issued, Price Per Share $ 1,000   $ 1,000        
Units Issued During Period, Units, New Issues 10,423            
Proceeds from Issuance or Sale of Equity, Total $ 6,173,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights [1]           $ 0.54  
Payments to Fund Clinical Research Trial $ 998,401            
API Development Funding and Access Agreement [Member]              
Development Agreement, Reimbursement Amount           $ 1,850,000  
Development Agreement, Reimbursement Proceeds   $ 800,000          
Unit Warrants [Member]              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 2,222            
Class of Warrant or Right, Purchase Price of Stock $ 0.45            
Class of Warrants or Rights, Warrant Proceeds if Exercised $ 11,600,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.50            
Series I Preferred Stock [Member]              
Convertible Preferred Stock, Shares Issued upon Conversion 2,222            
Units Sold in Exchange for Series D Preferred Stock [Member]              
Units Issued During Period, Units, New Issues 4,250            
Purchase Agreement [Member] | Vice Chairman of Board of Directors [Member]              
Debt Instrument, Face Amount         $ 2,500,000    
Proceeds from Issuance of Long-Term Debt, Total       $ 1,000,000.0 $ 1,500,000    
Debt Instrument, Interest Rate, Stated Percentage         8.00%    
CRG Loan Agreement, Texas Case [Member]              
Litigation Settlement, Amount Awarded to Other Party $ 2,600,000            
Loss Contingencies, Interest Rate             18.00%
Loss Contingency Accrual, Ending Balance           $ 3,385,429  
[1] Weighted average exercise price.