Annual report pursuant to Section 13 and 15(d)

Note 13 - Equity (Details Textual)

v3.23.1
Note 13 - Equity (Details Textual)
 1 Months Ended 6 Months Ended 10 Months Ended 12 Months Ended 16 Months Ended
Oct. 25, 2022
$ / shares
shares
Sep. 09, 2022
Aug. 30, 2022
USD ($)
$ / shares
shares
Aug. 03, 2022
$ / shares
shares
Jul. 01, 2022
USD ($)
Apr. 10, 2022
USD ($)
shares
Apr. 07, 2022
shares
Jul. 08, 2021
USD ($)
shares
Mar. 02, 2021
USD ($)
$ / shares
shares
Aug. 31, 2020
USD ($)
shares
Nov. 30, 2018
shares
Dec. 31, 2021
USD ($)
shares
Jul. 07, 2021
USD ($)
shares
Dec. 31, 2022
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
shares
Dec. 31, 2020
shares
Dec. 31, 2021
USD ($)
shares
Aug. 31, 2022
shares
Jan. 31, 2022
USD ($)
Stockholders' Equity Attributable to Noncontrolling Interest, Ending Balance | $                       $ 731,299   $ 292,518 $ 731,299   $ 731,299    
Additional Paid in Capital, Total | $                       $ 370,459,705   379,343,124 $ 370,459,705   $ 370,459,705    
Stock Issued During Period, Value, New Issues | $                           19,740          
Operating Loss Carryforwards | $                           $ 175,000,000          
Share Purchase Right, Shares Issuable Per Each Right             0.001                        
Share Purchase Right, Ownership Percentage Threshold             4.99%                        
Share Purchase Right, Ownership Percentage Trigger             0.50%                        
Share Purchase Right, Discount Percentage             50.00%                        
Rights Offering, Shares Authorized     35,000 35,000                              
Shares Issued, Price Per Share | $ / shares     $ 1,000 $ 1,000                              
Units Issued During Period, Units, New Issues     10,423                                
Proceeds from Issuance or Sale of Equity, Total | $     $ 6,173,000                                
Units Issued During Period, Value, New Issues | $     10,423,000                                
Payments to Fund Clinical Research Trial | $     $ 998,401                                
Stock Issued During Period, Shares, Employee Benefit Plan (in shares)                           53,238 30,018        
Stock Issued During Period, Value, Employee Benefit Plan | $                           $ 44,720 $ 76,846        
Stock Issued During Period, Value, Issued for Employee Bonuses | $                           $ 24,847 $ 76,846        
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares [1]                           $ 0.54          
Class of Warrant or Right, Outstanding                           23,363,966          
Common Stock, Capital Shares Reserved for Future Issuance                           24,066,771          
Minimum [Member]                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                           $ 0.50          
Warrants and Rights Outstanding, Term                           6 months          
Maximum [Member]                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                           $ 49.80          
Warrants and Rights Outstanding, Term                           4 years 8 months 12 days          
Weighted Average [Member]                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                           $ 0.54          
LTIP [Member]                                      
Stock Issued During Period, Shares, New Issues                           70,500          
Stock Issued During Period, Value, New Issues | $                           $ 19,740          
Incentive Plan, Milestone, Percent, Step of Total Stock Award Payout   5.00%                                  
Incentive Plan, Milestone, Percent, Regulatory Milestones   90.00%                                  
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage   100.00%                                  
Incentive Plan, Percent, Milestones Paid                           5.00%          
Common Stock [Member]                                      
Stock Issued During Period, Shares, New Issues                           70,500          
Stock Issued During Period, Value, New Issues | $                           $ 71          
Stock Issued During Period, Shares, Employee Benefit Plan (in shares)                           53,238          
Stock Issued During Period, Value, Employee Benefit Plan | $                           $ 53          
Stock Issued During Period, Shares, Issued for Employee Bonuses                           44,782 30,018        
Stock Issued During Period, Value, Issued for Employee Bonuses | $                           $ 45 $ 30        
Employees [Member] | Common Stock [Member]                                      
Stock Issued During Period, Shares, Issued for Employee Bonuses                           44,782          
Stock Issued During Period, Value, Issued for Employee Bonuses | $                           $ 24,847          
John K. Scott, Jr. [Member]                                      
Maximum Number of Units Purchasable     2,400                                
Director [Member]                                      
Common Stock, Capital Shares Reserved for Future Issuance                           102,869          
Former Chief Executive Officer and President [Member] | Common Stock [Member]                                      
Stock Issued During Period, Shares, New Issues                     925,000                
Stock Issued During Period, Shares, New Issues Placed in Escrow                     250,000     250,000          
Unit Warrants [Member]                                      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights     2,222                                
Class of Warrant or Right, Purchase Price of Stock | $ / shares     $ 0.45                                
Class of Warrants or Rights, Warrant Proceeds if Exercised | $     $ 11,600,000                                
Warrants and Rights Outstanding | $     $ 4,144,185                                
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares     $ 0.50                                
Unit Warrants [Member] | Measurement Input, Price Volatility [Member]                                      
Warrants and Rights Outstanding, Measurement Input     0.8925                                
Unit Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member]                                      
Warrants and Rights Outstanding, Measurement Input     0.0327                                
Unit Warrants [Member] | Measurement Input, Expected Dividend Payment [Member]                                      
Warrants and Rights Outstanding, Measurement Input     0                                
Series LL Warrants [Member]                                      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                           62,361          
Class of Warrant or Right, Exercises in Period 218,264                                    
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares $ 0.20                                    
Stock Issued During Period Shares Stock Warrants Exercised 62,361                                    
Bridge Loan [Member]                                      
Debt Instrument, Face Amount | $           $ 2,500,000                          
Proceeds from Issuance of Long-Term Debt, Total | $         $ 1,000,000.0 $ 1,500,000                          
Debt Instrument, Interest Rate, Stated Percentage           8.00%                          
Conversion from Series D Preferred Stock To Common Stock [Member]                                      
Conversion of Stock, Shares Converted                             54,750 17,750 72,500    
Conversion of Stock, Shares Issued                             2,951,509 827,280 3,778,789    
Common Stock, Capital Shares Reserved for Future Issuance                           21,064,560          
Series E Preferred Stock Exchanged for Sereis F and G Preferred Stock [Member]                                      
Conversion of Stock, Shares Converted           50,000                          
Series E Preferred Stock Exchanged for Sereis F Preferred Stock [Member]                                      
Conversion of Stock, Shares Issued           1,740                          
Series E Preferred Stock Exchanged for Sereis G Preferred Stock [Member]                                      
Conversion of Stock, Shares Issued           3,260                          
Units Sold in Exchange for Series D Preferred Stock [Member]                                      
Units Issued During Period, Units, New Issues     4,250                                
Convertible Preferred Stock, Fair Value | $                           $ 2,212,114          
Convertible Preferred Stock, Shares Issued Upon Conversion, Fair Value | $                           4,250,000          
Dividends, Preferred Stock, Total | $                           $ 2,037,886          
MT Preferred Stock [Member]                                      
Additional Paid in Capital, Total | $                                     $ 438,778
Series D Preferred Stock [Member]                                      
Stock Issued During Period, Value, New Issues | $                             $ 2,550,001        
Preferred Stock, Shares Outstanding, Ending Balance                       22,077   0 22,077   22,077    
Series D Preferred Stock [Member] | Common Stock [Member]                                      
Stock Issued During Period, Shares, New Issues                             0        
Stock Issued During Period, Value, New Issues | $                             $ 0        
Series D Preferred Stock [Member] | Keystone Capital Partners, LLC [Member]                                      
Stock Issued During Period, Shares, New Issues               22,077   150,000   77,500 72,500   76,827        
Stock Issued During Period, Value, Other | $                   $ 15,000,000.0                  
Convertible Preferred Stock, Discount to Market Rate                   10.00%                  
Convertible Preferred Stock, Maximum Allowed Percentage of Common Stock Outstanding Used in Conversion Shares                   19.99%                  
Convertible Preferred Stock, Shares Issued upon Conversion                                   5,147,000  
Stock Issued During Period, Value, New Issues | $               $ 2,200,000         $ 7,250,000   $ 7,700,000        
Preferred Stock, Shares Outstanding, Ending Balance                       22,077   0 22,077   22,077    
Series E Preferred Stock [Member]                                      
Stock Issued During Period, Value, New Issues | $                             $ 4,930,038        
Preferred Stock, Shares Outstanding, Ending Balance                       50,000   0 50,000   50,000    
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares                 $ 2.30                    
Preferred Stock, Redemption Price Per Share | $ / shares                 $ 110                    
Series E Preferred Stock [Member] | Common Stock [Member]                                      
Stock Issued During Period, Shares, New Issues                             0        
Stock Issued During Period, Value, New Issues | $                             $ 0        
Series E Preferred Stock [Member] | John K. Scott, Jr. [Member]                                      
Stock Issued During Period, Shares, New Issues                 50,000                    
Stock Issued During Period, Value, New Issues | $                 $ 5,000,000.0                    
Percentage of Securities Allowed to be Purchased in Third-Party Offering, Maximum                 33.33%                    
Series I Preferred Stock [Member]                                      
Convertible Preferred Stock, Shares Issued upon Conversion     2,222                                
Stock Issued During Period, Value, New Issues | $     $ 6,278,815                     $ 5,174,599          
Preferred Stock, Shares Outstanding, Ending Balance                       0   9,480 0   0    
Series I Preferred Stock [Member] | Common Stock [Member]                                      
Stock Issued During Period, Shares, New Issues                           0          
Stock Issued During Period, Value, New Issues | $                           $ 0          
MT [Member]                                      
Ownership Percentage                                     60.00%
Stockholders' Equity Attributable to Noncontrolling Interest, Ending Balance | $                                     $ 731,299
[1] Weighted average exercise price.