Annual report pursuant to Section 13 and 15(d)

Note 12 - Commitments and Contingencies (Details Textual)

Note 12 - Commitments and Contingencies (Details Textual) - USD ($)											1 Months Ended		12 Months Ended	19 Months Ended
	Jan. 30, 2023	Aug. 30, 2022	Dec. 09, 2021	Nov. 21, 2021	May 27, 2021	Mar. 16, 2021	Nov. 27, 2019	Apr. 09, 2018	Nov. 02, 2017	Mar. 03, 2017	Nov. 30, 2018	Jun. 30, 2016	Dec. 31, 2022	Mar. 31, 2022	Oct. 11, 2022	Jan. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Aug. 14, 2018
Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest, Ending Balance													$ (8,143,310)				$ 624,743	$ 2,046,907
Common Stock [Member]
Stock Issued During Period, Shares, New Issues													70,500
Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest, Ending Balance													$ 223,684				$ 221,277	$ 218,146
MT [Member]
Ownership Percentage																60.00%
Former Chief Executive Officer and President [Member]
Common Stock Shares Provided by Agreement																			1,175,000
Former Chief Executive Officer and President [Member] \| Common Stock [Member]
Stock Issued During Period, Shares, New Issues											925,000
Stock Issued During Period, Shares, New Issues Placed in Escrow											250,000		250,000
Former Chief Executive Officer and President [Member] \| MT [Member] \| Common Stock [Member] \| Dr. Michael Goldberg [Member]
Ownership Percentage																			5.00%
CRG [Member]
Draws on Letter of Credit								$ 7,153,000		$ 7,100,000
CRG Loan Agreement, Texas Case [Member]
Litigation Settlement, Attorneys’ Fees				$ 2,800,000
Litigation Settlement, Amount Awarded to Other Party		$ 2,600,000
Loss Contingencies, Interest Rate															18.00%
Loss Contingency Accrual, Ending Balance													$ 3,385,429
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount										7,000,000.0
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration								$ 4,200,000				$ 4,100,000
Ohio Court of Common Pleas [Member]
Litigation Settlement, Amount Awarded from Other Party							$ 4,300,000
Litigation Settlement, Reversal of Amount Awarded from Other Party						$ 4,300,000
Ohio Court of Common Pleas [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration												$ 4,100,000
Platinum-Montaur Life Sciences LLC Litigation [Member] \| Pending Litigation [Member]
Loss Contingency, Damages Sought, Value									$ 1,900,000
New York Litigation Involving Former CEO and President [Member] \| Judicial Ruling [Member]
Litigation Settlement, Amount Can Be Awarded to Other Party for Indemnification for Attorneys’ Fees					$ 14,955
Litigation Settlement, Amount Can Be Advanced to Other Party for Attorneys’ Fees Subject to Repayment					$ 1,237
Litigation Settlement, Advancement for Attorney's Fees and Disbursements														$ 143,172
New York Litigation Involving Former CEO and President [Member] \| Judicial Ruling [Member] \| Subsequent Event [Member]
Litigation Settlement, Amount Awarded to Other Party	$ 12,600
Delaware Litigation Involving Former CEO and President [Member]
Litigation Settlement, Amount Awarded from Other Party			$ 66,796
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Repayments of Debt										59,000,000.0
CRG [Member] \| Term Loan Agreement [Member] \| Maximum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount										66,000,000.0
CRG [Member] \| Term Loan Agreement [Member] \| Maximum [Member] \| Ohio Court of Common Pleas [Member]
Debt Instrument, Agreed-upon Final Payoff Amount										$ 66,000,000.0