Annual report pursuant to Section 13 and 15(d)

Note 2 - Liquidity (Details Textual)

Note 2 - Liquidity (Details Textual) - USD ($)							1 Months Ended
Note 2 - Liquidity (Details Textual) - USD ($)	Jan. 16, 2018	Nov. 02, 2017	Mar. 31, 2017	Mar. 03, 2017	Mar. 01, 2017	Jun. 22, 2016	Dec. 31, 2017	Feb. 28, 2017	Dec. 31, 2016	May 31, 2015
Estimated Litigation Liability, Current							$ 2,887,566
CRG Loan Agreement, Ohio Case [Member]
Release of Cash Held in Escrow				$ 2,000,000
CRG Loan Agreement, Texas Case [Member]
Release of Cash Held in Escrow				3,000,000
Estimated Litigation Liability, Current							2,900,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value, Additional Amount				7,000,000			7,000,000
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration							4,100,000
CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member] \| Subsequent Event [Member]
Loss Contingency, Damages Awarded, Value, Amount not Taken into Consideration	$ 4,100,000
CRG Loan Agreement, Texas Case [Member] \| Pending Litigation [Member] \| Subsequent Event [Member]
Loss Contingency, Damages Awarded,Value, Requested Modified Amount	$ 2,900,000
Platinum-Montaur Life Sciences LLC Litigation [Member] \| Pending Litigation [Member]
Loss Contingency, Damages Sought, Value		$ 1,914,827.22
Maximum [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Loss Contingency, Damages Awarded, Value				66,000,000			$ 66,000,000
Term Loan Agreement [Member] \| Cardinal Health 414 [Member]
Letters of Credit Outstanding, Amount				7,000,000
Term Loan Agreement [Member] \| CRG [Member]
Letters of Credit Outstanding, Amount				12,000,000
CRG [Member] \| Term Loan Agreement [Member]
Debt Instrument, Interest Rate, Stated Percentage								14.00%		14.00%
Debt Instrument, Default, Interest Rate, Stated Percentage								18.00%
Primary Bank Account Cash Taken Possession Of By Creditor						$ 4,100,000
Repayments of Debt				59,000,000
Debt Instrument, Final Payoff Amount, Threshold Above Which the Reporting Entity Will First Pay Without Resorting to Letter of Credit				59,000,000
CRG [Member] \| Term Loan Agreement [Member] \| CRG Loan Agreement, Texas Case [Member] \| Judicial Ruling [Member]
Repayments of Debt			$ 59,000,000	59,000,000	$ 59,000,000
CRG [Member] \| Term Loan Agreement [Member] \| Minimum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount				47,000,000
CRG [Member] \| Term Loan Agreement [Member] \| Maximum [Member]
Debt Instrument, Agreed-upon Final Payoff Amount				66,000,000
PPCO [Member] \| Platinum Loan Agreement [Member]
Repayments of Debt				7,700,000
Convertible Debt				$ 1,900,000