Note 21 - Segments - Segment Information (Details) - USD ($)
|
3 Months Ended |
12 Months Ended |
Dec. 31, 2017 |
Sep. 30, 2017 |
Jun. 30, 2017 |
Mar. 31, 2017 |
Dec. 31, 2016 |
Sep. 30, 2016 |
Jun. 30, 2016 |
Mar. 31, 2016 |
Dec. 31, 2017 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
$ 9,000
|
$ 18,000
|
$ 4,000
|
$ 9,000
|
|
|
$ 39,601
|
|
$ 19,075
|
|
Tc99m tilmanocept license revenue |
|
|
|
100,000
|
|
|
1,296,000
|
246,000
|
254,000
|
100,000
|
|
1,795,625
|
|
1,133,333
|
|
Tc99m tilmanocept royalty revenue |
|
9,000
|
|
|
|
|
|
|
|
9,126
|
|
|
|
|
|
Grant and other revenue |
|
386,000
|
224,000
|
512,000
|
580,000
|
1,022,000
|
511,000
|
917,000
|
686,000
|
1,701,311
|
|
3,136,408
|
|
1,860,953
|
|
Revenues |
|
|
|
|
|
|
|
|
|
1,810,437
|
|
4,971,634
|
|
3,013,361
|
|
Cost of goods sold |
|
|
|
|
|
|
|
|
|
3,651
|
|
62,260
|
|
3,226
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
4,513,842
|
|
7,138,080
|
|
10,562,729
|
|
Selling, general and administrative expenses, excluding depreciation and amortization (a) |
[1] |
|
|
|
|
|
|
|
|
10,929,785
|
|
7,466,487
|
|
10,365,950
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
240,166
|
|
453,549
|
|
522,196
|
|
Loss from operations (c) |
|
(3,521,000)
|
(2,385,000)
|
(4,823,000)
|
(3,148,000)
|
(3,240,000)
|
(910,000)
|
(2,241,000)
|
(3,758,000)
|
(13,877,007)
|
[3] |
(10,148,742)
|
[3] |
(18,440,740)
|
[3] |
Other income (expense) (d) |
|
|
|
|
|
|
|
|
|
(3,912,679)
|
[4] |
2,770,848
|
|
(4,603,857)
|
|
Benefit from income taxes |
|
201,000
|
776,000
|
1,631,000
|
1,454,000
|
|
|
|
|
4,062,489
|
|
|
|
|
|
Loss from continuing operations |
|
(6,170,000)
|
(1,541,000)
|
(3,152,000)
|
(2,865,000)
|
(2,118,000)
|
(1,761,000)
|
(817,000)
|
(2,682,000)
|
(13,727,197)
|
|
(7,377,894)
|
|
(23,044,597)
|
|
Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax |
|
|
|
|
|
|
|
|
|
89,163,811
|
|
|
|
|
|
Net income (loss) |
|
|
|
|
|
|
|
|
|
74,945,856
|
|
(14,309,031)
|
|
(27,563,535)
|
|
Total assets, net of depreciation and amortization |
|
20,781,436
|
|
|
|
12,461,676
|
|
|
|
20,781,436
|
|
12,461,676
|
|
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
33,690
|
|
1,847
|
|
39,001
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
62,260
|
|
3,226
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
2,786,007
|
|
(4,298,604)
|
|
Income (Loss) from Equity Method Investments |
|
|
|
|
|
|
|
|
|
|
|
(15,159)
|
|
(305,253)
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
|
|
(7,377,894)
|
|
(23,044,597)
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
2,112,000
|
$ 151,000
|
$ (2,036,000)
|
$ 88,446,000
|
(1,764,000)
|
$ 1,702,000
|
$ (5,865,000)
|
$ (1,004,000)
|
(490,758)
|
|
(6,931,137)
|
|
(4,518,938)
|
[5] |
UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
20,749,109
|
|
|
|
12,329,143
|
|
|
|
20,749,109
|
|
12,329,143
|
|
14,552,834
|
|
Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
39,601
|
|
19,075
|
|
Total assets, net of depreciation and amortization |
|
32,327
|
|
|
|
132,533
|
|
|
|
32,327
|
|
132,533
|
|
411,679
|
|
Diagnostics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
100,000
|
|
1,795,625
|
|
1,133,333
|
|
Tc99m tilmanocept royalty revenue |
|
|
|
|
|
|
|
|
|
9,126
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
1,506,232
|
|
3,011,642
|
|
1,860,953
|
|
Revenues |
|
|
|
|
|
|
|
|
|
1,615,358
|
|
4,846,868
|
|
3,013,361
|
|
Cost of goods sold |
|
|
|
|
|
|
|
|
|
3,651
|
|
|
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
3,784,255
|
|
6,375,929
|
|
9,831,834
|
|
Selling, general and administrative expenses, excluding depreciation and amortization (a) |
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
|
|
56,317
|
|
232,091
|
|
Loss from operations (c) |
[3] |
|
|
|
|
|
|
|
|
(2,172,548)
|
|
(1,647,638)
|
|
(7,053,790)
|
|
Other income (expense) (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Benefit from income taxes |
|
|
|
|
|
|
|
|
|
496,127
|
|
|
|
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
(1,676,421)
|
|
|
|
|
|
Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax |
|
|
|
|
|
|
|
|
|
88,673,053
|
|
|
|
|
|
Net income (loss) |
|
|
|
|
|
|
|
|
|
86,996,632
|
|
(8,578,775)
|
|
(12,767,388)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
|
|
|
26,589
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
62,260
|
|
3,226
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Income (Loss) from Equity Method Investments |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
|
|
(1,647,638)
|
|
(7,053,790)
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
(6,931,137)
|
|
(5,713,598)
|
[5] |
Diagnostics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
13,065,871
|
|
|
|
3,815,271
|
|
|
|
13,065,871
|
|
3,815,271
|
|
4,161,029
|
|
Diagnostics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
39,601
|
|
19,075
|
|
Total assets, net of depreciation and amortization |
|
30,476
|
|
|
|
131,752
|
|
|
|
30,476
|
|
131,752
|
|
410,666
|
|
Therapeutics Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept royalty revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
195,079
|
|
124,766
|
|
|
|
Revenues |
|
|
|
|
|
|
|
|
|
195,079
|
|
124,766
|
|
|
|
Cost of goods sold |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
729,587
|
|
762,151
|
|
730,895
|
|
Selling, general and administrative expenses, excluding depreciation and amortization (a) |
[1] |
|
|
|
|
|
|
|
|
34,484
|
|
63,158
|
|
123,884
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Loss from operations (c) |
[3] |
|
|
|
|
|
|
|
|
(568,992)
|
|
(700,543)
|
|
(854,779)
|
|
Other income (expense) (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Benefit from income taxes |
|
|
|
|
|
|
|
|
|
129,936
|
|
|
|
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
(439,056)
|
|
|
|
|
|
Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
|
|
|
|
|
|
|
|
(439,056)
|
|
(700,543)
|
|
(854,779)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Income (Loss) from Equity Method Investments |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
|
|
(700,543)
|
|
(854,779)
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
[5] |
Therapeutics Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
49,001
|
|
|
|
15,075
|
|
|
|
49,001
|
|
15,075
|
|
|
|
Therapeutics Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Corporate Segment [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept license revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc99m tilmanocept royalty revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Grant and other revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenues |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cost of goods sold |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Selling, general and administrative expenses, excluding depreciation and amortization (a) |
[1] |
|
|
|
|
|
|
|
|
10,895,301
|
|
7,403,329
|
|
10,242,066
|
|
Depreciation, Depletion and Amortization, Nonproduction |
[2] |
|
|
|
|
|
|
|
|
240,166
|
|
397,232
|
|
290,105
|
|
Loss from operations (c) |
[3] |
|
|
|
|
|
|
|
|
(11,135,467)
|
|
(7,800,561)
|
|
(10,532,171)
|
|
Other income (expense) (d) |
[4] |
|
|
|
|
|
|
|
|
(3,912,679)
|
|
|
|
|
|
Benefit from income taxes |
|
|
|
|
|
|
|
|
|
3,436,426
|
|
|
|
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
(11,611,720)
|
|
|
|
|
|
Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net income (loss) |
|
|
|
|
|
|
|
|
|
(11,611,720)
|
|
(5,029,713)
|
|
(13,941,368)
|
|
Capital expenditures |
|
|
|
|
|
|
|
|
|
33,690
|
|
1,847
|
|
12,412
|
|
Cost of goods sold, excluding depreciation and amortization |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other income (expense), excluding equity in the loss of R-NAV, LLC (d) |
[4] |
|
|
|
|
|
|
|
|
|
|
2,786,007
|
|
(4,298,604)
|
|
Income (Loss) from Equity Method Investments |
|
|
|
|
|
|
|
|
|
|
|
(15,159)
|
|
(305,253)
|
|
Loss from continuing operations |
|
|
|
|
|
|
|
|
|
|
|
(5,029,713)
|
|
(15,136,028)
|
|
Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax |
|
|
|
|
|
|
|
|
|
|
|
|
|
1,194,660
|
[5] |
Corporate Segment [Member] | UNITED STATES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
7,634,237
|
|
|
|
8,498,797
|
|
|
|
7,634,237
|
|
8,498,797
|
|
10,391,805
|
|
Corporate Segment [Member] | Non-US [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tc 99m tilmanocept sales revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total assets, net of depreciation and amortization |
|
$ 1,851
|
|
|
|
$ 781
|
|
|
|
$ 1,851
|
|
$ 781
|
|
$ 1,013
|
|
|
|