Annual report pursuant to Section 13 and 15(d)

Note 18 - Equity Instruments (Details Textual)

Note 18 - Equity Instruments (Details Textual) - USD ($)		1 Months Ended				3 Months Ended	12 Months Ended
	Mar. 03, 2017	Mar. 31, 2017	Jan. 31, 2017	Oct. 31, 2015	Sep. 30, 2015	Sep. 30, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Mar. 11, 2015
Class of Warrant or Right, Outstanding							16,932,517
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 1.19
Issuance of Stock and Warrants for Services or Claims									$ 256,450
Common Stock, Capital Shares Reserved for Future Issuance							20,620,196
Chief Executive Officer [Member]
Class of Warrant or Right, Exercises in Period			5,411,850
Stock Issued During Period, Shares, Issued for Exercise of Warrants			5,411.85
Proceeds from Warrant Exercises			$ 54,119
Series BB [Member]
Class of Warrant or Right, Outstanding							300,000
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 2
Gains (Losses) on Extension of Warrant Expiration Date						$ 150,000
Series MM Warrants Expire September 2019 [Member]
Class of Warrant or Right, Outstanding							150,000
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 2.50
Series MM Warrants Expire September 2019 [Member] \| Chardan Capital Markets, LLC [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights					$ 2.50	$ 2.50
Class of Warrant or Right, Outstanding Term					4 years
Common Stock Warrants Issued					150,000
Series MM Warrants Expire October 2019 [Member]
Class of Warrant or Right, Outstanding							150,000
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 2.50
Series MM Warrants Expire October 2019 [Member] \| Chardan Capital Markets, LLC [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights				$ 2.50
Class of Warrant or Right, Outstanding Term				4 years
Common Stock Warrants Issued				150,000
Series MM warrants [Member] \| Chardan Capital Markets, LLC [Member]
Issuance of Stock and Warrants for Services or Claims						$ 256,000
Series LL Warrants [Member]
Class of Warrant or Right, Outstanding							4,365,280
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 0.01
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Exercised				5,000,000
Stock Issued During Period Shares Stock Warrants Exercised				4,977,679
Series NN Warrants [Member]
Class of Warrant or Right, Outstanding							11,000,000
Class of Warrant or Right, Exercise Price of Warrants or Rights		$ 1.50					$ 1.50
Class of Warrant or Right, Term		5 years
Series NN Warrants [Member] \| Cardinal Health 414 [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		10,000,000
Series NN Warrants [Member] \| UCSD [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 1.50
Class of Warrant or Right, Number of Securities Called by Warrants or Rights	1,000,000	1,000,000					1,000,000
Class of Warrant or Right, Term	5 years
Common Stock [Member]
Stock Issued During Period, Shares, Issued for Exercise of Warrants							5,411,850
Common Stock [Member] \| Macrophage Therapeutics [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 2,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights							300			300
Minimum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 0.01
Maximum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights							$ 3.04